May LT - Search Results

1

Capadenoson, a clinically trialed partial adenosine A₁ receptor agonist, can stimulate adenosine A_2B receptor biased agonism.

Baltos JA, Vecchio EA, Harris MA, Qin CX, Ritchie RH, Christopoulos A, White PJ, May LT. Baltos JA, et al. Among authors: may lt. Biochem Pharmacol. 2017 Jul 1;135:79-89. doi: 10.1016/j.bcp.2017.03.014. Epub 2017 Mar 23. Biochem Pharmacol. 2017. PMID: 28344125

2

Allosteric modulators of G-protein-coupled receptors.

May LT, Christopoulos A. May LT, et al. Curr Opin Pharmacol. 2003 Oct;3(5):551-6. doi: 10.1016/s1471-4892(03)00107-3. Curr Opin Pharmacol. 2003. PMID: 14559102 Review.

3

Application of a kinetic model to the apparently complex behavior of negative and positive allosteric modulators of muscarinic acetylcholine receptors.

Avlani V, May LT, Sexton PM, Christopoulos A. Avlani V, et al. Among authors: may lt. J Pharmacol Exp Ther. 2004 Mar;308(3):1062-72. doi: 10.1124/jpet.103.059840. Epub 2004 Jan 7. J Pharmacol Exp Ther. 2004. PMID: 14711931

4

Allosteric modulation of G protein-coupled receptors.

May LT, Avlani VA, Sexton PM, Christopoulos A. May LT, et al. Curr Pharm Des. 2004;10(17):2003-13. doi: 10.2174/1381612043384303. Curr Pharm Des. 2004. PMID: 15279541 Review.

5

Regulation of M2 muscarinic acetylcholine receptor expression and signaling by prolonged exposure to allosteric modulators.

May LT, Lin Y, Sexton PM, Christopoulos A. May LT, et al. J Pharmacol Exp Ther. 2005 Jan;312(1):382-90. doi: 10.1124/jpet.104.073767. Epub 2004 Aug 27. J Pharmacol Exp Ther. 2005. PMID: 15333678

6

G-protein-coupled receptor allosterism: the promise and the problem(s).

Christopoulos A, May LT, Avlani VA, Sexton PM. Christopoulos A, et al. Among authors: may lt. Biochem Soc Trans. 2004 Nov;32(Pt 5):873-7. doi: 10.1042/BST0320873. Biochem Soc Trans. 2004. PMID: 15494038 Review.

7

Effects of urea pretreatment on the binding properties of adenosine A1 receptors.

May LT, Sexton PM, Christopoulos A. May LT, et al. Br J Pharmacol. 2005 Dec;146(8):1119-29. doi: 10.1038/sj.bjp.0706419. Br J Pharmacol. 2005. PMID: 16231004 Free PMC article.

8

Allosteric modulation of G protein-coupled receptors.

May LT, Leach K, Sexton PM, Christopoulos A. May LT, et al. Annu Rev Pharmacol Toxicol. 2007;47:1-51. doi: 10.1146/annurev.pharmtox.47.120505.105159. Annu Rev Pharmacol Toxicol. 2007. PMID: 17009927 Review.

9

Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors.

May LT, Avlani VA, Langmead CJ, Herdon HJ, Wood MD, Sexton PM, Christopoulos A. May LT, et al. Mol Pharmacol. 2007 Aug;72(2):463-76. doi: 10.1124/mol.107.037630. Epub 2007 May 24. Mol Pharmacol. 2007. PMID: 17525129

10

Allosteric modulation of endogenous metabolites as an avenue for drug discovery.

Wootten D, Savage EE, Valant C, May LT, Sloop KW, Ficorilli J, Showalter AD, Willard FS, Christopoulos A, Sexton PM. Wootten D, et al. Among authors: may lt. Mol Pharmacol. 2012 Aug;82(2):281-90. doi: 10.1124/mol.112.079319. Epub 2012 May 10. Mol Pharmacol. 2012. PMID: 22576254

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