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A Genomic DNA Reporter Screen Identifies Squalene Synthase Inhibitors That Act Cooperatively with Statins to Upregulate the Low-Density Lipoprotein Receptor.
Kerr AG, Tam LCS, Hale AB, Cioroch M, Douglas G, Agkatsev S, Hibbitt O, Mason J, Holt-Martyn J, Bataille CJR, Wynne GM, Channon KM, Russell AJ, Wade-Martins R. Kerr AG, et al. Among authors: tam lcs. J Pharmacol Exp Ther. 2017 Jun;361(3):417-428. doi: 10.1124/jpet.116.239574. Epub 2017 Mar 30. J Pharmacol Exp Ther. 2017. PMID: 28360334 Free PMC article.
Preclinical evaluation of FLT190, a liver-directed AAV gene therapy for Fabry disease.
Jeyakumar JM, Kia A, Tam LCS, McIntosh J, Spiewak J, Mills K, Heywood W, Chisari E, Castaldo N, Verhoef D, Hosseini P, Kalcheva P, Cocita C, Miranda CJ, Canavese M, Khinder J, Rosales C, Hughes D, Sheridan R, Corbau R, Nathwani A. Jeyakumar JM, et al. Among authors: tam lcs. Gene Ther. 2023 Jun;30(6):487-502. doi: 10.1038/s41434-022-00381-y. Epub 2023 Jan 11. Gene Ther. 2023. PMID: 36631545 Free PMC article.
Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma.
O'Callaghan J, Crosbie DE, Cassidy PS, Sherwood JM, Flügel-Koch C, Lütjen-Drecoll E, Humphries MM, Reina-Torres E, Wallace D, Kiang AS, Campbell M, Stamer WD, Overby DR, O'Brien C, Tam LCS, Humphries P. O'Callaghan J, et al. Among authors: tam lcs. Hum Mol Genet. 2017 Apr 1;26(7):1230-1246. doi: 10.1093/hmg/ddx028. Hum Mol Genet. 2017. PMID: 28158775 Free PMC article.
Enhancement of Outflow Facility in the Murine Eye by Targeting Selected Tight-Junctions of Schlemm's Canal Endothelia.
Tam LC, Reina-Torres E, Sherwood JM, Cassidy PS, Crosbie DE, Lütjen-Drecoll E, Flügel-Koch C, Perkumas K, Humphries MM, Kiang AS, O'Callaghan J, Callanan JJ, Read AT, Ethier CR, O'Brien C, Lawrence M, Campbell M, Stamer WD, Overby DR, Humphries P. Tam LC, et al. Sci Rep. 2017 Jan 16;7:40717. doi: 10.1038/srep40717. Sci Rep. 2017. PMID: 28091584 Free PMC article.
17 results