Shi H - Search Results

1

Insights into Watson-Crick/Hoogsteen breathing dynamics and damage repair from the solution structure and dynamic ensemble of DNA duplexes containing m1A.

Sathyamoorthy B, Shi H, Zhou H, Xue Y, Rangadurai A, Merriman DK, Al-Hashimi HM. Sathyamoorthy B, et al. Among authors: shi h. Nucleic Acids Res. 2017 May 19;45(9):5586-5601. doi: 10.1093/nar/gkx186. Nucleic Acids Res. 2017. PMID: 28369571 Free PMC article.

2

Atomic structures of excited state A-T Hoogsteen base pairs in duplex DNA by combining NMR relaxation dispersion, mutagenesis, and chemical shift calculations.

Shi H, Clay MC, Rangadurai A, Sathyamoorthy B, Case DA, Al-Hashimi HM. Shi H, et al. J Biomol NMR. 2018 Apr;70(4):229-244. doi: 10.1007/s10858-018-0177-2. Epub 2018 Apr 19. J Biomol NMR. 2018. PMID: 29675775 Free PMC article.

3

Increasing the length of poly-pyrimidine bulges broadens RNA conformational ensembles with minimal impact on stacking energetics.

Merriman DK, Yuan J, Shi H, Majumdar A, Herschlag D, Al-Hashimi HM. Merriman DK, et al. Among authors: shi h. RNA. 2018 Oct;24(10):1363-1376. doi: 10.1261/rna.066258.118. Epub 2018 Jul 16. RNA. 2018. PMID: 30012568 Free PMC article.

4

Why are Hoogsteen base pairs energetically disfavored in A-RNA compared to B-DNA?

Rangadurai A, Zhou H, Merriman DK, Meiser N, Liu B, Shi H, Szymanski ES, Al-Hashimi HM. Rangadurai A, et al. Among authors: shi h. Nucleic Acids Res. 2018 Nov 16;46(20):11099-11114. doi: 10.1093/nar/gky885. Nucleic Acids Res. 2018. PMID: 30285154 Free PMC article.

5

Characterizing micro-to-millisecond chemical exchange in nucleic acids using off-resonance R_1ρ relaxation dispersion.

Rangadurai A, Szymaski ES, Kimsey IJ, Shi H, Al-Hashimi HM. Rangadurai A, et al. Among authors: shi h. Prog Nucl Magn Reson Spectrosc. 2019 Jun-Aug;112-113:55-102. doi: 10.1016/j.pnmrs.2019.05.002. Epub 2019 May 11. Prog Nucl Magn Reson Spectrosc. 2019. PMID: 31481159 Free PMC article. Review.

6

Direct evidence for (G)O6···H₂-N4(C)⁺ hydrogen bonding in transient G(syn)-C⁺ and G(syn)-m⁵C⁺ Hoogsteen base pairs in duplex DNA from cytosine amino nitrogen off-resonance R_1ρ relaxation dispersion measurements.

Rangadurai A, Kremser J, Shi H, Kreutz C, Al-Hashimi HM. Rangadurai A, et al. Among authors: shi h. J Magn Reson. 2019 Nov;308:106589. doi: 10.1016/j.jmr.2019.106589. Epub 2019 Sep 5. J Magn Reson. 2019. PMID: 31539864 Free PMC article.

7

NMR Chemical Exchange Measurements Reveal That N⁶-Methyladenosine Slows RNA Annealing.

Shi H, Liu B, Nussbaumer F, Rangadurai A, Kreutz C, Al-Hashimi HM. Shi H, et al. J Am Chem Soc. 2019 Dec 26;141(51):19988-19993. doi: 10.1021/jacs.9b10939. Epub 2019 Dec 16. J Am Chem Soc. 2019. PMID: 31826614 Free PMC article.

8

Extending the Sensitivity of CEST NMR Spectroscopy to Micro-to-Millisecond Dynamics in Nucleic Acids Using High-Power Radio-Frequency Fields.

Rangadurai A, Shi H, Al-Hashimi HM. Rangadurai A, et al. Among authors: shi h. Angew Chem Int Ed Engl. 2020 Jul 6;59(28):11262-11266. doi: 10.1002/anie.202000493. Epub 2020 May 11. Angew Chem Int Ed Engl. 2020. PMID: 32168407 Free PMC article.

9

Probing conformational transitions towards mutagenic Watson-Crick-like G·T mismatches using off-resonance sugar carbon R_1ρ relaxation dispersion.

Rangadurai A, Szymanski ES, Kimsey I, Shi H, Al-Hashimi HM. Rangadurai A, et al. Among authors: shi h. J Biomol NMR. 2020 Sep;74(8-9):457-471. doi: 10.1007/s10858-020-00337-7. Epub 2020 Aug 12. J Biomol NMR. 2020. PMID: 32789613 Free PMC article.

10

Hoogsteen base pairs increase the susceptibility of double-stranded DNA to cytotoxic damage.

Xu Y, Manghrani A, Liu B, Shi H, Pham U, Liu A, Al-Hashimi HM. Xu Y, et al. Among authors: shi h. J Biol Chem. 2020 Nov 20;295(47):15933-15947. doi: 10.1074/jbc.RA120.014530. Epub 2020 Sep 10. J Biol Chem. 2020. PMID: 32913127 Free PMC article.

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