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SAR110894, a potent histamine H3-receptor antagonist, displays disease-modifying activity in a transgenic mouse model of tauopathy.
Delay-Goyet P, Blanchard V, Schussler N, Lopez-Grancha M, Ménager J, Mary V, Sultan E, Buzy A, Guillemot JC, Stemmelin J, Bertrand P, Rooney T, Pradier L, Barnéoud P. Delay-Goyet P, et al. Among authors: rooney t. Alzheimers Dement (N Y). 2016 Nov 3;2(4):267-280. doi: 10.1016/j.trci.2016.10.002. eCollection 2016 Nov. Alzheimers Dement (N Y). 2016. PMID: 29067314 Free PMC article.
High-throughput 3D whole-brain quantitative histopathology in rodents.
Vandenberghe ME, Hérard AS, Souedet N, Sadouni E, Santin MD, Briet D, Carré D, Schulz J, Hantraye P, Chabrier PE, Rooney T, Debeir T, Blanchard V, Pradier L, Dhenain M, Delzescaux T. Vandenberghe ME, et al. Among authors: rooney t. Sci Rep. 2016 Feb 15;6:20958. doi: 10.1038/srep20958. Sci Rep. 2016. PMID: 26876372 Free PMC article.
Development of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson's disease.
Lesuisse D, Malanda A, Peyronel JF, Evanno Y, Lardenois P, De-Peretti D, Abécassis PY, Barnéoud P, Brunel P, Burgevin MC, Cegarra C, Auger F, Dommergue A, Lafon C, Even L, Tsi J, Luc TPH, Almario A, Olivier A, Castel MN, Taupin V, Rooney T, Vigé X. Lesuisse D, et al. Among authors: rooney t. Bioorg Med Chem Lett. 2019 Apr 1;29(7):929-932. doi: 10.1016/j.bmcl.2019.01.024. Epub 2019 Jan 30. Bioorg Med Chem Lett. 2019. PMID: 30773432
Increased regional cerebral glucose uptake in an APP/PS1 model of Alzheimer's disease.
Poisnel G, Hérard AS, El Tannir El Tayara N, Bourrin E, Volk A, Kober F, Delatour B, Delzescaux T, Debeir T, Rooney T, Benavides J, Hantraye P, Dhenain M. Poisnel G, et al. Among authors: rooney t. Neurobiol Aging. 2012 Sep;33(9):1995-2005. doi: 10.1016/j.neurobiolaging.2011.09.026. Epub 2011 Nov 12. Neurobiol Aging. 2012. PMID: 22079157 Free PMC article.
211 results