Li Y - Search Results

1

Synthesis and biological evaluation of morpholine-substituted diphenylpyrimidine derivatives (Mor-DPPYs) as potent EGFR T790M inhibitors with improved activity toward the gefitinib-resistant non-small cell lung cancers (NSCLC).

Song Z, Huang S, Yu H, Jiang Y, Wang C, Meng Q, Shu X, Sun H, Liu K, Li Y, Ma X. Song Z, et al. Among authors: li y. Eur J Med Chem. 2017 Jun 16;133:329-339. doi: 10.1016/j.ejmech.2017.03.083. Epub 2017 Apr 2. Eur J Med Chem. 2017. PMID: 28395219

2

Novel 4-anilinoquinazoline derivatives featuring an 1-adamantyl moiety as potent EGFR inhibitors with enhanced activity against NSCLC cell lines.

Yu H, Li Y, Ge Y, Song Z, Wang C, Huang S, Jin Y, Han X, Zhen Y, Liu K, Zhou Y, Ma X. Yu H, et al. Among authors: li y. Eur J Med Chem. 2016 Mar 3;110:195-203. doi: 10.1016/j.ejmech.2016.01.045. Epub 2016 Jan 26. Eur J Med Chem. 2016. PMID: 26829280

3

Synthesis and biological evaluation of azole-diphenylpyrimidine derivatives (AzDPPYs) as potent T790M mutant form of epidermal growth factor receptor inhibitors.

Song Z, Jin Y, Ge Y, Wang C, Zhang J, Tang Z, Peng J, Liu K, Li Y, Ma X. Song Z, et al. Among authors: li y. Bioorg Med Chem. 2016 Nov 1;24(21):5505-5512. doi: 10.1016/j.bmc.2016.09.001. Epub 2016 Sep 3. Bioorg Med Chem. 2016. PMID: 27634676

4

Novel Selective and Potent EGFR Inhibitor that Overcomes T790M-Mediated Resistance in Non-Small Cell Lung Cancer.

Li Y, Song Z, Jin Y, Tang Z, Kang J, Ma X. Li Y, et al. Molecules. 2016 Nov 2;21(11):1462. doi: 10.3390/molecules21111462. Molecules. 2016. PMID: 27827863 Free PMC article.

5

Structural optimization of diphenylpyrimidine derivatives (DPPYs) as potent Bruton's tyrosine kinase (BTK) inhibitors with improved activity toward B leukemia cell lines.

Zhao D, Huang S, Qu M, Wang C, Liu Z, Li Z, Peng J, Liu K, Li Y, Ma X, Shu X. Zhao D, et al. Among authors: li y, li z. Eur J Med Chem. 2017 Jan 27;126:444-455. doi: 10.1016/j.ejmech.2016.11.047. Epub 2016 Nov 23. Eur J Med Chem. 2017. PMID: 27912175

6

Design and synthesis of phosphoryl-substituted diphenylpyrimidines (Pho-DPPYs) as potent Bruton's tyrosine kinase (BTK) inhibitors: Targeted treatment of B lymphoblastic leukemia cell lines.

Ge Y, Yang H, Wang C, Meng Q, Li L, Sun H, Zhen Y, Liu K, Li Y, Ma X. Ge Y, et al. Among authors: li y, li l. Bioorg Med Chem. 2017 Jan 15;25(2):765-772. doi: 10.1016/j.bmc.2016.11.054. Epub 2016 Nov 29. Bioorg Med Chem. 2017. PMID: 27956037

7

Discovery of Novel Bruton's Tyrosine Kinase (BTK) Inhibitors Bearing a N,9-Diphenyl-9H-purin-2-amine Scaffold.

Ge Y, Jin Y, Wang C, Zhang J, Tang Z, Peng J, Liu K, Li Y, Zhou Y, Ma X. Ge Y, et al. Among authors: li y. ACS Med Chem Lett. 2016 Sep 21;7(12):1050-1055. doi: 10.1021/acsmedchemlett.6b00235. eCollection 2016 Dec 8. ACS Med Chem Lett. 2016. PMID: 27994736 Free PMC article.

8

C-2 (E)-4-(Styryl)aniline substituted diphenylpyrimidine derivatives (Sty-DPPYs) as specific kinase inhibitors targeting clinical resistance related EGFR^T790M mutant.

Song A, Zhang J, Ge Y, Wang C, Meng Q, Tang Z, Peng J, Liu K, Li Y, Ma X. Song A, et al. Among authors: li y. Bioorg Med Chem. 2017 May 15;25(10):2724-2729. doi: 10.1016/j.bmc.2017.03.032. Epub 2017 Mar 18. Bioorg Med Chem. 2017. PMID: 28385595

9

Design and synthesis of sulfonamide-substituted diphenylpyrimidines (SFA-DPPYs) as potent Bruton's tyrosine kinase (BTK) inhibitors with improved activity toward B-cell lymphoblastic leukemia.

Liu H, Qu M, Xu L, Han X, Wang C, Shu X, Yao J, Liu K, Peng J, Li Y, Ma X. Liu H, et al. Among authors: li y. Eur J Med Chem. 2017 Jul 28;135:60-69. doi: 10.1016/j.ejmech.2017.04.037. Epub 2017 Apr 14. Eur J Med Chem. 2017. PMID: 28432946

10

Covalent binding design strategy: A prospective method for discovery of potent targeted anticancer agents.

Wang L, Zhao J, Yao Y, Wang C, Zhang J, Shu X, Sun X, Li Y, Liu K, Yuan H, Ma X. Wang L, et al. Among authors: li y. Eur J Med Chem. 2017 Dec 15;142:493-505. doi: 10.1016/j.ejmech.2017.09.024. Epub 2017 Sep 20. Eur J Med Chem. 2017. PMID: 28986130 Review.

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