Walker GS - Search Results

1

Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides.

Thakare R, Gao H, Kosa RE, Bi YA, Varma MVS, Cerny MA, Sharma R, Kuhn M, Huang B, Liu Y, Yu A, Walker GS, Niosi M, Tremaine L, Alnouti Y, Rodrigues AD. Thakare R, et al. Among authors: walker gs. Drug Metab Dispos. 2017 Jul;45(7):721-733. doi: 10.1124/dmd.117.075275. Epub 2017 Apr 10. Drug Metab Dispos. 2017. PMID: 28396527

2

The use of 18O-exchange and base-catalyzed N-dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites.

Bessire AJ, Vaz AD, Walker GS, Wang WW, Sharma R. Bessire AJ, et al. Among authors: walker gs. Rapid Commun Mass Spectrom. 2010 Jul 30;24(14):2151-61. doi: 10.1002/rcm.4595. Rapid Commun Mass Spectrom. 2010. PMID: 20552706

3

Validation of isolated metabolites from drug metabolism studies as analytical standards by quantitative NMR.

Walker GS, Ryder TF, Sharma R, Smith EB, Freund A. Walker GS, et al. Drug Metab Dispos. 2011 Mar;39(3):433-40. doi: 10.1124/dmd.110.036343. Epub 2010 Nov 22. Drug Metab Dispos. 2011. PMID: 21098098

4

Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity.

Lee CA, Jones JP 3rd, Katayama J, Kaspera R, Jiang Y, Freiwald S, Smith E, Walker GS, Totah RA. Lee CA, et al. Among authors: walker gs. Drug Metab Dispos. 2012 May;40(5):943-51. doi: 10.1124/dmd.111.043505. Epub 2012 Feb 10. Drug Metab Dispos. 2012. PMID: 22328583 Free PMC article.

5

Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs.

Walsky RL, Obach RS, Hyland R, Kang P, Zhou S, West M, Geoghegan KF, Helal CJ, Walker GS, Goosen TC, Zientek MA. Walsky RL, et al. Among authors: walker gs. Drug Metab Dispos. 2012 Sep;40(9):1686-97. doi: 10.1124/dmd.112.045302. Epub 2012 May 29. Drug Metab Dispos. 2012. PMID: 22645092

6

Characterization of T-5 N-oxide formation as the first highly selective measure of CYP3A5 activity.

Li X, Jeso V, Heyward S, Walker GS, Sharma R, Micalizio GC, Cameron MD. Li X, et al. Among authors: walker gs. Drug Metab Dispos. 2014 Mar;42(3):334-42. doi: 10.1124/dmd.113.054726. Epub 2013 Dec 11. Drug Metab Dispos. 2014. PMID: 24335391 Free PMC article.

7

The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans.

Dowty ME, Lin J, Ryder TF, Wang W, Walker GS, Vaz A, Chan GL, Krishnaswami S, Prakash C. Dowty ME, et al. Among authors: walker gs. Drug Metab Dispos. 2014 Apr;42(4):759-73. doi: 10.1124/dmd.113.054940. Epub 2014 Jan 24. Drug Metab Dispos. 2014. PMID: 24464803

8

Biosynthesis of drug metabolites and quantitation using NMR spectroscopy for use in pharmacologic and drug metabolism studies.

Walker GS, Bauman JN, Ryder TF, Smith EB, Spracklin DK, Obach RS. Walker GS, et al. Drug Metab Dispos. 2014 Oct;42(10):1627-39. doi: 10.1124/dmd.114.059204. Epub 2014 Jul 22. Drug Metab Dispos. 2014. PMID: 25053618

9

In Vitro Kinetic Characterization of Axitinib Metabolism.

Zientek MA, Goosen TC, Tseng E, Lin J, Bauman JN, Walker GS, Kang P, Jiang Y, Freiwald S, Neul D, Smith BJ. Zientek MA, et al. Among authors: walker gs. Drug Metab Dispos. 2016 Jan;44(1):102-14. doi: 10.1124/dmd.115.065615. Epub 2015 Oct 28. Drug Metab Dispos. 2016. PMID: 26512042

10

Lead Diversification at the Nanomole Scale Using Liver Microsomes and Quantitative Nuclear Magnetic Resonance Spectroscopy: Application to Phosphodiesterase 2 Inhibitors.

Obach RS, Walker GS, Sharma R, Jenkinson S, Tran TP, Stepan AF. Obach RS, et al. Among authors: walker gs. J Med Chem. 2018 Apr 26;61(8):3626-3640. doi: 10.1021/acs.jmedchem.8b00116. Epub 2018 Apr 9. J Med Chem. 2018. PMID: 29601185

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