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Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.
Walker AL, Ancellin N, Beaufils B, Bergeal M, Binnie M, Bouillot A, Clapham D, Denis A, Haslam CP, Holmes DS, Hutchinson JP, Liddle J, McBride A, Mirguet O, Mowat CG, Rowland P, Tiberghien N, Trottet L, Uings I, Webster SP, Zheng X, Mole DJ. Walker AL, et al. Among authors: binnie m. J Med Chem. 2017 Apr 27;60(8):3383-3404. doi: 10.1021/acs.jmedchem.7b00055. Epub 2017 Apr 11. J Med Chem. 2017. PMID: 28398044 Free article.
Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors.
Webster SP, Ward P, Binnie M, Craigie E, McConnell KM, Sooy K, Vinter A, Seckl JR, Walker BR. Webster SP, et al. Among authors: binnie m. Bioorg Med Chem Lett. 2007 May 15;17(10):2838-43. doi: 10.1016/j.bmcl.2007.02.057. Epub 2007 Feb 25. Bioorg Med Chem Lett. 2007. PMID: 17350260
Antidiabetic activity of N-(6-substituted-1,3-benzothiazol-2-yl)benzenesulfonamides.
Moreno-Díaz H, Villalobos-Molina R, Ortiz-Andrade R, Díaz-Coutiño D, Medina-Franco JL, Webster SP, Binnie M, Estrada-Soto S, Ibarra-Barajas M, León-Rivera I, Navarrete-Vázquez G. Moreno-Díaz H, et al. Among authors: binnie m. Bioorg Med Chem Lett. 2008 May 1;18(9):2871-7. doi: 10.1016/j.bmcl.2008.03.086. Epub 2008 Apr 8. Bioorg Med Chem Lett. 2008. PMID: 18424136
A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition.
Torres-Piedra M, Ortiz-Andrade R, Villalobos-Molina R, Singh N, Medina-Franco JL, Webster SP, Binnie M, Navarrete-Vázquez G, Estrada-Soto S. Torres-Piedra M, et al. Among authors: binnie m. Eur J Med Chem. 2010 Jun;45(6):2606-12. doi: 10.1016/j.ejmech.2010.02.049. Epub 2010 Mar 1. Eur J Med Chem. 2010. PMID: 20346546
Synthesis of 2-{2-[(α/β-naphthalen-1-ylsulfonyl)amino]-1,3-thiazol-4-yl} acetamides with 11β-hydroxysteroid dehydrogenase inhibition and in combo antidiabetic activities.
Navarrete-Vázquez G, Morales-Vilchis MG, Estrada-Soto S, Ramírez-Espinosa JJ, Hidalgo-Figueroa S, Nava-Zuazo C, Tlahuext H, Leon-Rivera I, Medina-Franco JL, López-Vallejo F, Webster SP, Binnie M, Ortiz-Andrade R, Moreno-Diaz H. Navarrete-Vázquez G, et al. Among authors: binnie m. Eur J Med Chem. 2014 Mar 3;74:179-86. doi: 10.1016/j.ejmech.2013.12.042. Epub 2014 Jan 8. Eur J Med Chem. 2014. PMID: 24462849
99 results