Ye N - Search Results

1

Identification of novel 2-(benzo[d]isoxazol-3-yl)-2-oxo-N-phenylacetohydrazonoyl cyanide analoguesas potent EPAC antagonists.

Ye N, Zhu Y, Liu Z, Mei FC, Chen H, Wang P, Cheng X, Zhou J. Ye N, et al. Eur J Med Chem. 2017 Jul 7;134:62-71. doi: 10.1016/j.ejmech.2017.04.001. Epub 2017 Apr 4. Eur J Med Chem. 2017. PMID: 28399451 Free PMC article.

2

Further SAR study on 11-O-substituted aporphine analogues: identification of highly potent dopamine D3 receptor ligands.

Ye N, Wu Q, Zhu L, Zheng L, Gao B, Zhen X, Zhang A. Ye N, et al. Bioorg Med Chem. 2011 Mar 15;19(6):1999-2008. doi: 10.1016/j.bmc.2011.01.053. Epub 2011 Jan 31. Bioorg Med Chem. 2011. PMID: 21334902

3

Identification of N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate as a new anti-Parkinson's agent possessing a dopamine D2 and serotonin 5-HT1A dual-agonist profile.

Zhang H, Ye N, Zhou S, Guo L, Zheng L, Liu Z, Gao B, Zhen X, Zhang A. Zhang H, et al. Among authors: ye n. J Med Chem. 2011 Jul 14;54(13):4324-38. doi: 10.1021/jm200347t. Epub 2011 Jun 2. J Med Chem. 2011. PMID: 21591752

4

Oridonin ring A-based diverse constructions of enone functionality: identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis.

Ding C, Zhang Y, Chen H, Yang Z, Wild C, Ye N, Ester CD, Xiong A, White MA, Shen Q, Zhou J. Ding C, et al. Among authors: ye n. J Med Chem. 2013 Nov 14;56(21):8814-25. doi: 10.1021/jm401248x. Epub 2013 Oct 31. J Med Chem. 2013. PMID: 24128046 Free PMC article.

5

Recent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).

Chen H, Wild C, Zhou X, Ye N, Cheng X, Zhou J. Chen H, et al. Among authors: ye n. J Med Chem. 2014 May 8;57(9):3651-65. doi: 10.1021/jm401425e. Epub 2013 Nov 27. J Med Chem. 2014. PMID: 24256330 Free PMC article. Review.

6

Small molecule inhibitors targeting activator protein 1 (AP-1).

Ye N, Ding Y, Wild C, Shen Q, Zhou J. Ye N, et al. J Med Chem. 2014 Aug 28;57(16):6930-48. doi: 10.1021/jm5004733. Epub 2014 May 27. J Med Chem. 2014. PMID: 24831826 Free PMC article.

7

Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3).

Chen H, Yang Z, Ding C, Xiong A, Wild C, Wang L, Ye N, Cai G, Flores RM, Ding Y, Shen Q, Zhou J. Chen H, et al. Among authors: ye n. Eur J Med Chem. 2014 Jul 23;82:195-203. doi: 10.1016/j.ejmech.2014.05.049. Epub 2014 May 22. Eur J Med Chem. 2014. PMID: 24904966 Free PMC article.

8

ent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels-Alder reactions: synthesis of dihydropyran-fused diterpenoids.

Ding C, Wang L, Chen H, Wild C, Ye N, Ding Y, Wang T, White MA, Shen Q, Zhou J. Ding C, et al. Among authors: ye n. Org Biomol Chem. 2014 Nov 14;12(42):8442-52. doi: 10.1039/c4ob01040j. Org Biomol Chem. 2014. PMID: 25225052 Free PMC article.

9

Biochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors: defining the ESI-09 "therapeutic window".

Zhu Y, Chen H, Boulton S, Mei F, Ye N, Melacini G, Zhou J, Cheng X. Zhu Y, et al. Among authors: ye n. Sci Rep. 2015 Mar 20;5:9344. doi: 10.1038/srep09344. Sci Rep. 2015. PMID: 25791905 Free PMC article.

10

Structure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists.

Ye N, Zhu Y, Chen H, Liu Z, Mei FC, Wild C, Chen H, Cheng X, Zhou J. Ye N, et al. J Med Chem. 2015 Aug 13;58(15):6033-47. doi: 10.1021/acs.jmedchem.5b00635. Epub 2015 Jul 16. J Med Chem. 2015. PMID: 26151319 Free PMC article.

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