Hernandez-Alba O - Search Results

1

Insights from native mass spectrometry approaches for top- and middle- level characterization of site-specific antibody-drug conjugates.

Botzanowski T, Erb S, Hernandez-Alba O, Ehkirch A, Colas O, Wagner-Rousset E, Rabuka D, Beck A, Drake PM, Cianférani S. Botzanowski T, et al. MAbs. 2017 Jul;9(5):801-811. doi: 10.1080/19420862.2017.1316914. Epub 2017 Apr 13. MAbs. 2017. PMID: 28406343 Free PMC article.

2

Adding a new separation dimension to MS and LC-MS: What is the utility of ion mobility spectrometry?

D'Atri V, Causon T, Hernandez-Alba O, Mutabazi A, Veuthey JL, Cianferani S, Guillarme D. D'Atri V, et al. J Sep Sci. 2018 Jan;41(1):20-67. doi: 10.1002/jssc.201700919. Epub 2017 Nov 23. J Sep Sci. 2018. PMID: 29024509 Review.

3

An Online Four-Dimensional HIC×SEC-IM×MS Methodology for Proof-of-Concept Characterization of Antibody Drug Conjugates.

Ehkirch A, D'Atri V, Rouviere F, Hernandez-Alba O, Goyon A, Colas O, Sarrut M, Beck A, Guillarme D, Heinisch S, Cianferani S. Ehkirch A, et al. Anal Chem. 2018 Feb 6;90(3):1578-1586. doi: 10.1021/acs.analchem.7b02110. Epub 2018 Jan 5. Anal Chem. 2018. PMID: 29260862 Free article.

4

Hyphenation of size exclusion chromatography to native ion mobility mass spectrometry for the analytical characterization of therapeutic antibodies and related products.

Ehkirch A, Hernandez-Alba O, Colas O, Beck A, Guillarme D, Cianférani S. Ehkirch A, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jun 1;1086:176-183. doi: 10.1016/j.jchromb.2018.04.010. Epub 2018 Apr 12. J Chromatogr B Analyt Technol Biomed Life Sci. 2018. PMID: 29684909

5

Native Mass Spectrometry, Ion Mobility, and Collision-Induced Unfolding for Conformational Characterization of IgG4 Monoclonal Antibodies.

Hernandez-Alba O, Wagner-Rousset E, Beck A, Cianférani S. Hernandez-Alba O, et al. Anal Chem. 2018 Aug 7;90(15):8865-8872. doi: 10.1021/acs.analchem.8b00912. Epub 2018 Jul 16. Anal Chem. 2018. PMID: 29956914

6

A Novel Online Four-Dimensional SEC×SEC-IM×MS Methodology for Characterization of Monoclonal Antibody Size Variants.

Ehkirch A, Goyon A, Hernandez-Alba O, Rouviere F, D'Atri V, Dreyfus C, Haeuw JF, Diemer H, Beck A, Heinisch S, Guillarme D, Cianferani S. Ehkirch A, et al. Anal Chem. 2018 Dec 4;90(23):13929-13937. doi: 10.1021/acs.analchem.8b03333. Epub 2018 Nov 12. Anal Chem. 2018. PMID: 30371058

7

Cutting-edge multi-level analytical and structural characterization of antibody-drug conjugates: present and future.

Beck A, D'Atri V, Ehkirch A, Fekete S, Hernandez-Alba O, Gahoual R, Leize-Wagner E, François Y, Guillarme D, Cianférani S. Beck A, et al. Expert Rev Proteomics. 2019 Apr;16(4):337-362. doi: 10.1080/14789450.2019.1578215. Epub 2019 Feb 18. Expert Rev Proteomics. 2019. PMID: 30706723 Review.

8

A Case Study to Identify the Drug Conjugation Site of a Site-Specific Antibody-Drug-Conjugate Using Middle-Down Mass Spectrometry.

Hernandez-Alba O, Houel S, Hessmann S, Erb S, Rabuka D, Huguet R, Josephs J, Beck A, Drake PM, Cianférani S. Hernandez-Alba O, et al. J Am Soc Mass Spectrom. 2019 Nov;30(11):2419-2429. doi: 10.1007/s13361-019-02296-2. Epub 2019 Aug 19. J Am Soc Mass Spectrom. 2019. PMID: 31429052

9

Analysis of ADCs by Native Mass Spectrometry.

Hernandez-Alba O, Ehkirch A, Beck A, Cianférani S. Hernandez-Alba O, et al. Methods Mol Biol. 2020;2078:197-211. doi: 10.1007/978-1-4939-9929-3_13. Methods Mol Biol. 2020. PMID: 31643058

10

Glycan-Mediated Technology for Obtaining Homogeneous Site-Specific Conjugated Antibody-Drug Conjugates: Synthesis and Analytical Characterization by Using Complementary Middle-up LC/HRMS Analysis.

Duivelshof BL, Deslignière E, Hernandez-Alba O, Ehkirch A, Toftevall H, Sjögren J, Cianferani S, Beck A, Guillarme D, D'Atri V. Duivelshof BL, et al. Anal Chem. 2020 Jun 16;92(12):8170-8177. doi: 10.1021/acs.analchem.0c00282. Epub 2020 May 29. Anal Chem. 2020. PMID: 32407621

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