Rabuka D - Search Results

1

Insights from native mass spectrometry approaches for top- and middle- level characterization of site-specific antibody-drug conjugates.

Botzanowski T, Erb S, Hernandez-Alba O, Ehkirch A, Colas O, Wagner-Rousset E, Rabuka D, Beck A, Drake PM, Cianférani S. Botzanowski T, et al. Among authors: rabuka d. MAbs. 2017 Jul;9(5):801-811. doi: 10.1080/19420862.2017.1316914. Epub 2017 Apr 13. MAbs. 2017. PMID: 28406343 Free PMC article.

2

An emerging playbook for antibody-drug conjugates: lessons from the laboratory and clinic suggest a strategy for improving efficacy and safety.

Drake PM, Rabuka D. Drake PM, et al. Among authors: rabuka d. Curr Opin Chem Biol. 2015 Oct;28:174-80. doi: 10.1016/j.cbpa.2015.08.005. Epub 2015 Sep 2. Curr Opin Chem Biol. 2015. PMID: 26342601 Review.

3

Antibody-drug conjugate library prepared by scanning insertion of the aldehyde tag into IgG1 constant regions.

Huang BCB, Kim YC, Bañas S, Barfield RM, Drake PM, Rupniewski I, Haskins WE, Rabuka D. Huang BCB, et al. Among authors: rabuka d. MAbs. 2018 Nov-Dec;10(8):1182-1189. doi: 10.1080/19420862.2018.1512327. Epub 2018 Sep 25. MAbs. 2018. PMID: 30252630 Free PMC article.

4

A Case Study to Identify the Drug Conjugation Site of a Site-Specific Antibody-Drug-Conjugate Using Middle-Down Mass Spectrometry.

Hernandez-Alba O, Houel S, Hessmann S, Erb S, Rabuka D, Huguet R, Josephs J, Beck A, Drake PM, Cianférani S. Hernandez-Alba O, et al. Among authors: rabuka d. J Am Soc Mass Spectrom. 2019 Nov;30(11):2419-2429. doi: 10.1007/s13361-019-02296-2. Epub 2019 Aug 19. J Am Soc Mass Spectrom. 2019. PMID: 31429052

5

Exploring the effects of linker composition on site-specifically modified antibody-drug conjugates.

Albers AE, Garofalo AW, Drake PM, Kudirka R, de Hart GW, Barfield RM, Baker J, Banas S, Rabuka D. Albers AE, et al. Among authors: rabuka d. Eur J Med Chem. 2014 Dec 17;88:3-9. doi: 10.1016/j.ejmech.2014.08.062. Epub 2014 Aug 23. Eur J Med Chem. 2014. PMID: 25176286

6

A simple LC/MRM-MS-based method to quantify free linker-payload in antibody-drug conjugate preparations.

Zmolek W, Bañas S, Barfield RM, Rabuka D, Drake PM. Zmolek W, et al. Among authors: rabuka d. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 1;1032:144-148. doi: 10.1016/j.jchromb.2016.05.055. Epub 2016 Jun 1. J Chromatogr B Analyt Technol Biomed Life Sci. 2016. PMID: 27311685

7

Recent Developments in ADC Technology: Preclinical Studies Signal Future Clinical Trends.

Drake PM, Rabuka D. Drake PM, et al. Among authors: rabuka d. BioDrugs. 2017 Dec;31(6):521-531. doi: 10.1007/s40259-017-0254-1. BioDrugs. 2017. PMID: 29119409 Free PMC article. Review.

8

Tandem-Cleavage Linkers Improve the In Vivo Stability and Tolerability of Antibody-Drug Conjugates.

Chuprakov S, Ogunkoya AO, Barfield RM, Bauzon M, Hickle C, Kim YC, Yeo D, Zhang F, Rabuka D, Drake PM. Chuprakov S, et al. Among authors: rabuka d. Bioconjug Chem. 2021 Apr 21;32(4):746-754. doi: 10.1021/acs.bioconjchem.1c00029. Epub 2021 Mar 9. Bioconjug Chem. 2021. PMID: 33689309 Free article.

9

Site-Specific Tandem Knoevenagel Condensation-Michael Addition To Generate Antibody-Drug Conjugates.

Kudirka RA, Barfield RM, McFarland JM, Drake PM, Carlson A, Bañas S, Zmolek W, Garofalo AW, Rabuka D. Kudirka RA, et al. Among authors: rabuka d. ACS Med Chem Lett. 2016 Aug 30;7(11):994-998. doi: 10.1021/acsmedchemlett.6b00253. eCollection 2016 Nov 10. ACS Med Chem Lett. 2016. PMID: 27882197 Free PMC article.

10

CAT-02-106, a Site-Specifically Conjugated Anti-CD22 Antibody Bearing an MDR1-Resistant Maytansine Payload Yields Excellent Efficacy and Safety in Preclinical Models.

Drake PM, Carlson A, McFarland JM, Bañas S, Barfield RM, Zmolek W, Kim YC, Huang BCB, Kudirka R, Rabuka D. Drake PM, et al. Among authors: rabuka d. Mol Cancer Ther. 2018 Jan;17(1):161-168. doi: 10.1158/1535-7163.MCT-17-0776. Epub 2017 Nov 15. Mol Cancer Ther. 2018. PMID: 29142069

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