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Lowered PON1 activities are strongly associated with depression and bipolar disorder, recurrence of (hypo)mania and depression, increased disability and lowered quality of life.
Moreira EG, Correia DG, Bonifácio KL, Moraes JB, Cavicchioli FL, Nunes CS, Nunes SOV, Vargas HO, Barbosa DS, Maes M. Moreira EG, et al. Among authors: cavicchioli fl. World J Biol Psychiatry. 2019 Jun;20(5):368-380. doi: 10.1080/15622975.2017.1322219. Epub 2017 May 30. World J Biol Psychiatry. 2019. PMID: 28441923