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In vitro and in vivo antitumor activities of T-3764518, a novel and orally available small molecule stearoyl-CoA desaturase 1 inhibitor.
Nishizawa S, Sumi H, Satoh Y, Yamamoto Y, Kitazawa S, Honda K, Araki H, Kakoi K, Imamura K, Sasaki M, Miyahisa I, Satomi Y, Nishigaki R, Hirayama M, Aoyama K, Maezaki H, Hara T. Nishizawa S, et al. Among authors: hirayama m. Eur J Pharmacol. 2017 Jul 15;807:21-31. doi: 10.1016/j.ejphar.2017.03.064. Epub 2017 Apr 22. Eur J Pharmacol. 2017. PMID: 28442322
Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents.
Imamura K, Tomita N, Kawakita Y, Ito Y, Ono K, Nii N, Miyazaki T, Yonemori K, Tawada M, Sumi H, Satoh Y, Yamamoto Y, Miyahisa I, Sasaki M, Satomi Y, Hirayama M, Nishigaki R, Maezaki H. Imamura K, et al. Among authors: hirayama m. Bioorg Med Chem. 2017 Jul 15;25(14):3768-3779. doi: 10.1016/j.bmc.2017.05.016. Epub 2017 May 11. Bioorg Med Chem. 2017. PMID: 28571972
Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents.
Kojima T, Asano Y, Kurasawa O, Hirata Y, Iwamura N, Wong TT, Saito B, Tanaka Y, Arai R, Yonemori K, Miyamoto Y, Sagiya Y, Yaguchi M, Shibata S, Mizutani A, Sano O, Adachi R, Satomi Y, Hirayama M, Aoyama K, Hiura Y, Kiba A, Kitamura S, Imamura S. Kojima T, et al. Among authors: hirayama m. Bioorg Med Chem. 2018 May 15;26(9):2452-2465. doi: 10.1016/j.bmc.2018.04.008. Epub 2018 Apr 4. Bioorg Med Chem. 2018. PMID: 29669694
Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats.
Gopalan V, Michael N, Ishino S, Lee SS, Yang AY, Bhanu Prakash KN, Yaligar J, Sadananthan SA, Kaneko M, Zhou Z, Satomi Y, Hirayama M, Kamiguchi H, Zhu B, Horiguchi T, Nishimoto T, Velan SS. Gopalan V, et al. Among authors: hirayama m. Sci Rep. 2016 May 20;6:26445. doi: 10.1038/srep26445. Sci Rep. 2016. PMID: 27197769 Free PMC article.
Metabolomic/lipidomic-based analysis of plasma to diagnose hepatocellular ballooning in patients with non-alcoholic fatty liver disease: A multicenter study.
Ogawa Y, Kobayashi T, Honda Y, Kessoku T, Tomeno W, Imajo K, Nakahara T, Oeda S, Nagaoki Y, Amano Y, Ando T, Hirayama M, Isono O, Kamiguchi H, Nagabukuro H, Ogawa S, Satomi Y, Saigusa Y, Takahashi H, Hyogo H, Yoneda M, Saito S, Yamanaka T, Aishima S, Eguchi Y, Kage M, Chayama K, Nakajima A. Ogawa Y, et al. Among authors: hirayama m. Hepatol Res. 2020 Aug;50(8):955-965. doi: 10.1111/hepr.13528. Epub 2020 Jul 15. Hepatol Res. 2020. PMID: 32455496
916 results