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Biosynthesis of proresolving lipid mediators by vascular cells and tissues.
Chatterjee A, Komshian S, Sansbury BE, Wu B, Mottola G, Chen M, Spite M, Conte MS. Chatterjee A, et al. FASEB J. 2017 Aug;31(8):3393-3402. doi: 10.1096/fj.201700082R. Epub 2017 Apr 25. FASEB J. 2017. PMID: 28442547 Free PMC article.
Primary cultures of human saphenous vein endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) converted 17-HDHA to SPMs, including resolvin D1 (RvD1) and other D-series resolvins and protectins. This was accompanied by a rapid translocation of 5-LOX from nucleu …
Primary cultures of human saphenous vein endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) converted 17-HDHA to SPMs, includi …
D-series resolvins inhibit murine abdominal aortic aneurysm formation and increase M2 macrophage polarization.
Pope NH, Salmon M, Davis JP, Chatterjee A, Su G, Conte MS, Ailawadi G, Upchurch GR Jr. Pope NH, et al. Among authors: chatterjee a. FASEB J. 2016 Dec;30(12):4192-4201. doi: 10.1096/fj.201600144RR. Epub 2016 Sep 12. FASEB J. 2016. PMID: 27619672 Free PMC article.
Treatment of existing small AAAs with RvD2 demonstrated a 25% reduction in aneurysm size at d 14 compared to vehicle alone (P = 0.018). Confocal histology demonstrated a prevalence of M2 macrophages within the aortic medium in mice treated with RvD2. ...-Pope, N. H. …
Treatment of existing small AAAs with RvD2 demonstrated a 25% reduction in aneurysm size at d 14 compared to vehicle alone (P = 0.018 …
4,115 results