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Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis.
Barnham KJ, McKinstry WJ, Multhaup G, Galatis D, Morton CJ, Curtain CC, Williamson NA, White AR, Hinds MG, Norton RS, Beyreuther K, Masters CL, Parker MW, Cappai R. Barnham KJ, et al. Among authors: masters cl. J Biol Chem. 2003 May 9;278(19):17401-7. doi: 10.1074/jbc.M300629200. Epub 2003 Feb 28. J Biol Chem. 2003. PMID: 12611883 Free article.
Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation.
Barnham KJ, Ciccotosto GD, Tickler AK, Ali FE, Smith DG, Williamson NA, Lam YH, Carrington D, Tew D, Kocak G, Volitakis I, Separovic F, Barrow CJ, Wade JD, Masters CL, Cherny RA, Curtain CC, Bush AI, Cappai R. Barnham KJ, et al. Among authors: masters cl. J Biol Chem. 2003 Oct 31;278(44):42959-65. doi: 10.1074/jbc.M305494200. Epub 2003 Aug 18. J Biol Chem. 2003. PMID: 12925530 Free article.
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial.
Ritchie CW, Bush AI, Mackinnon A, Macfarlane S, Mastwyk M, MacGregor L, Kiers L, Cherny R, Li QX, Tammer A, Carrington D, Mavros C, Volitakis I, Xilinas M, Ames D, Davis S, Beyreuther K, Tanzi RE, Masters CL. Ritchie CW, et al. Among authors: masters cl. Arch Neurol. 2003 Dec;60(12):1685-91. doi: 10.1001/archneur.60.12.1685. Arch Neurol. 2003. PMID: 14676042 Clinical Trial.
Neurodegenerative diseases and oxidative stress.
Barnham KJ, Masters CL, Bush AI. Barnham KJ, et al. Among authors: masters cl. Nat Rev Drug Discov. 2004 Mar;3(3):205-14. doi: 10.1038/nrd1330. Nat Rev Drug Discov. 2004. PMID: 15031734 Review.
1,012 results