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A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme.
Dumoulin M, Last AM, Desmyter A, Decanniere K, Canet D, Larsson G, Spencer A, Archer DB, Sasse J, Muyldermans S, Wyns L, Redfield C, Matagne A, Robinson CV, Dobson CM. Dumoulin M, et al. Among authors: muyldermans s. Nature. 2003 Aug 14;424(6950):783-8. doi: 10.1038/nature01870. Nature. 2003. PMID: 12917687 Free article.
Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils.
Chan PH, Pardon E, Menzer L, De Genst E, Kumita JR, Christodoulou J, Saerens D, Brans A, Bouillenne F, Archer DB, Robinson CV, Muyldermans S, Matagne A, Redfield C, Wyns L, Dobson CM, Dumoulin M. Chan PH, et al. Among authors: muyldermans s. Biochemistry. 2008 Oct 21;47(42):11041-54. doi: 10.1021/bi8005797. Epub 2008 Sep 25. Biochemistry. 2008. PMID: 18816062
290 results