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Hexamethylene amiloride engages a novel reactive oxygen species- and lysosome-dependent programmed necrotic mechanism to selectively target breast cancer cells.
Rowson-Hodel AR, Berg AL, Wald JH, Hatakeyama J, VanderVorst K, Curiel DA, Leon LJ, Sweeney C, Carraway KL 3rd. Rowson-Hodel AR, et al. Among authors: vandervorst k. Cancer Lett. 2016 May 28;375(1):62-72. doi: 10.1016/j.canlet.2016.02.042. Epub 2016 Mar 2. Cancer Lett. 2016. PMID: 26944316 Free PMC article.
Membrane Mucin Muc4 promotes blood cell association with tumor cells and mediates efficient metastasis in a mouse model of breast cancer.
Rowson-Hodel AR, Wald JH, Hatakeyama J, O'Neal WK, Stonebraker JR, VanderVorst K, Saldana MJ, Borowsky AD, Sweeney C, Carraway KL 3rd. Rowson-Hodel AR, et al. Among authors: vandervorst k. Oncogene. 2018 Jan 11;37(2):197-207. doi: 10.1038/onc.2017.327. Epub 2017 Sep 11. Oncogene. 2018. PMID: 28892049 Free PMC article.
The role of membrane mucin MUC4 in breast cancer metastasis.
Dreyer CA, VanderVorst K, Free S, Rowson-Hodel A, Carraway KL. Dreyer CA, et al. Among authors: vandervorst k. Endocr Relat Cancer. 2021 Nov 24;29(1):R17-R32. doi: 10.1530/ERC-21-0083. Endocr Relat Cancer. 2021. PMID: 34726614 Free PMC article. Review.
The Cationic Amphiphilic Drug Hexamethylene Amiloride Eradicates Bulk Breast Cancer Cells and Therapy-Resistant Subpopulations with Similar Efficiencies.
Berg AL, Rowson-Hodel A, Hu M, Keeling M, Wu H, VanderVorst K, Chen JJ, Hatakeyama J, Jilek J, Dreyer CA, Wheeler MR, Yu AM, Li Y, Carraway KL 3rd. Berg AL, et al. Among authors: vandervorst k. Cancers (Basel). 2022 Feb 14;14(4):949. doi: 10.3390/cancers14040949. Cancers (Basel). 2022. PMID: 35205696 Free PMC article.
13 results