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Unravelling the transcriptional responses of TGF-β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification.
Andrews D, Oliviero G, De Chiara L, Watson A, Rochford E, Wynne K, Kennedy C, Clerkin S, Doyle B, Godson C, Connell P, O'Brien C, Cagney G, Crean J. Andrews D, et al. FASEB J. 2019 May;33(5):6667-6681. doi: 10.1096/fj.201800566RR. Epub 2019 Feb 19. FASEB J. 2019. PMID: 30779601
We propose that the interaction between Smad3 and EZH2 targets the core polycomb assembly to defined regions of the genome to regulate transcriptional repression and forms a molecular switch that controls promoter access through epigenetic mechanisms leading to gene silencing.- …
We propose that the interaction between Smad3 and EZH2 targets the core polycomb assembly to defined regions of the genome to regulate trans …
Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis.
Beaton H, Andrews D, Parsons M, Murphy M, Gaffney A, Kavanagh D, McKay GJ, Maxwell AP, Taylor CT, Cummins EP, Godson C, Higgins DF, Murphy P, Crean J. Beaton H, et al. Among authors: andrews d. Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F35-45. doi: 10.1152/ajprenal.00136.2016. Epub 2016 Apr 27. Am J Physiol Renal Physiol. 2016. PMID: 27122540 Free article.
Small molecule protein assembly modulators with pan-cancer therapeutic efficacy.
Lingappa AF, Akintunde O, Samueli E, Ewald C, Michon M, Ziari N, Lu M, Yu SF, Froehlich M, Le PU, Fernandez Y, Mallesh S, Lin J, Kitaygorodskyy A, Solas D, Reed JC, Lingappa JR, Müller-Schiffmann A, Korth C, Prasad D, Nalca A, Aston E, Fabbri B, Anand SK, Campi TW, Petrouski E, Dey D, Andrews DW, Rubenstein JL, Lingappa VR. Lingappa AF, et al. Among authors: andrews dw. Open Biol. 2024 Dec;14(12):240210. doi: 10.1098/rsob.240210. Epub 2024 Dec 18. Open Biol. 2024. PMID: 39689856 Free PMC article.
1,261 results