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Statin Use After Diagnosis of Colon Cancer and Patient Survival.
Voorneveld PW, Reimers MS, Bastiaannet E, Jacobs RJ, van Eijk R, Zanders MMJ, Herings RMC, van Herk-Sukel MPP, Kodach LL, van Wezel T, Kuppen PJK, Morreau H, van de Velde CJH, Hardwick JCH, Liefers GJ. Voorneveld PW, et al. Gastroenterology. 2017 Aug;153(2):470-479.e4. doi: 10.1053/j.gastro.2017.05.011. Epub 2017 May 13. Gastroenterology. 2017. PMID: 28512021
Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway.
Kodach LL, Jacobs RJ, Voorneveld PW, Wildenberg ME, Verspaget HW, van Wezel T, Morreau H, Hommes DW, Peppelenbosch MP, van den Brink GR, Hardwick JC. Kodach LL, et al. Among authors: voorneveld pw. Gut. 2011 Nov;60(11):1544-53. doi: 10.1136/gut.2011.237495. Epub 2011 May 6. Gut. 2011. PMID: 21551187
Cholesterol metabolism and colorectal cancers.
Jacobs RJ, Voorneveld PW, Kodach LL, Hardwick JC. Jacobs RJ, et al. Among authors: voorneveld pw. Curr Opin Pharmacol. 2012 Dec;12(6):690-5. doi: 10.1016/j.coph.2012.07.010. Epub 2012 Aug 8. Curr Opin Pharmacol. 2012. PMID: 22884562 Review.
Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.
Voorneveld PW, Kodach LL, Jacobs RJ, Liv N, Zonnevylle AC, Hoogenboom JP, Biemond I, Verspaget HW, Hommes DW, de Rooij K, van Noesel CJ, Morreau H, van Wezel T, Offerhaus GJ, van den Brink GR, Peppelenbosch MP, Ten Dijke P, Hardwick JC. Voorneveld PW, et al. Gastroenterology. 2014 Jul;147(1):196-208.e13. doi: 10.1053/j.gastro.2014.03.052. Epub 2014 Apr 3. Gastroenterology. 2014. PMID: 24704720
The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC.
Voorneveld PW, Kodach LL, Jacobs RJ, van Noesel CJ, Peppelenbosch MP, Korkmaz KS, Molendijk I, Dekker E, Morreau H, van Pelt GW, Tollenaar RA, Mesker W, Hawinkels LJ, Paauwe M, Verspaget HW, Geraets DT, Hommes DW, Offerhaus GJ, van den Brink GR, Ten Dijke P, Hardwick JC. Voorneveld PW, et al. Br J Cancer. 2015 Jan 6;112(1):122-30. doi: 10.1038/bjc.2014.560. Epub 2014 Nov 13. Br J Cancer. 2015. PMID: 25393365 Free PMC article.
Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met.
Burggraaf J, Kamerling IM, Gordon PB, Schrier L, de Kam ML, Kales AJ, Bendiksen R, Indrevoll B, Bjerke RM, Moestue SA, Yazdanfar S, Langers AM, Swaerd-Nordmo M, Torheim G, Warren MV, Morreau H, Voorneveld PW, Buckle T, van Leeuwen FW, Ødegårdstuen LI, Dalsgaard GT, Healey A, Hardwick JC. Burggraaf J, et al. Among authors: voorneveld pw. Nat Med. 2015 Aug;21(8):955-61. doi: 10.1038/nm.3641. Epub 2015 Jul 13. Nat Med. 2015. PMID: 26168295
17 results