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Nesprin 1 is critical for nuclear positioning and anchorage.
Zhang J, Felder A, Liu Y, Guo LT, Lange S, Dalton ND, Gu Y, Peterson KL, Mizisin AP, Shelton GD, Lieber RL, Chen J. Zhang J, et al. Hum Mol Genet. 2010 Jan 15;19(2):329-41. doi: 10.1093/hmg/ddp499. Epub 2009 Oct 28. Hum Mol Genet. 2010. PMID: 19864491 Free PMC article.
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.
Zhang D, Contu R, Latronico MV, Zhang J, Rizzi R, Catalucci D, Miyamoto S, Huang K, Ceci M, Gu Y, Dalton ND, Peterson KL, Guan KL, Brown JH, Chen J, Sonenberg N, Condorelli G. Zhang D, et al. Among authors: zhang j. J Clin Invest. 2010 Aug;120(8):2805-16. doi: 10.1172/JCI43008. Epub 2010 Jul 19. J Clin Invest. 2010. PMID: 20644257 Free PMC article.
Thymosin beta 4 is dispensable for murine cardiac development and function.
Banerjee I, Zhang J, Moore-Morris T, Lange S, Shen T, Dalton ND, Gu Y, Peterson KL, Evans SM, Chen J. Banerjee I, et al. Among authors: zhang j. Circ Res. 2012 Feb 3;110(3):456-64. doi: 10.1161/CIRCRESAHA.111.258616. Epub 2011 Dec 8. Circ Res. 2012. PMID: 22158707 Free PMC article.
The nebulin SH3 domain is dispensable for normal skeletal muscle structure but is required for effective active load bearing in mouse.
Yamamoto DL, Vitiello C, Zhang J, Gokhin DS, Castaldi A, Coulis G, Piaser F, Filomena MC, Eggenhuizen PJ, Kunderfranco P, Camerini S, Takano K, Endo T, Crescenzi M, Luther PK, Lieber RL, Chen J, Bang ML. Yamamoto DL, et al. Among authors: zhang j. J Cell Sci. 2013 Dec 1;126(Pt 23):5477-89. doi: 10.1242/jcs.137026. Epub 2013 Sep 17. J Cell Sci. 2013. PMID: 24046450 Free PMC article.
Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.
Banerjee I, Zhang J, Moore-Morris T, Pfeiffer E, Buchholz KS, Liu A, Ouyang K, Stroud MJ, Gerace L, Evans SM, McCulloch A, Chen J. Banerjee I, et al. Among authors: zhang j. PLoS Genet. 2014 Feb 20;10(2):e1004114. doi: 10.1371/journal.pgen.1004114. eCollection 2014 Feb. PLoS Genet. 2014. PMID: 24586179 Free PMC article.
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