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The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1.
Yonezawa T, Takahashi H, Shikata S, Liu X, Tamura M, Asada S, Fukushima T, Fukuyama T, Tanaka Y, Sawasaki T, Kitamura T, Goyama S. Yonezawa T, et al. Among authors: fukushima t. J Biol Chem. 2017 Jul 28;292(30):12528-12541. doi: 10.1074/jbc.M117.785675. Epub 2017 May 23. J Biol Chem. 2017. PMID: 28536267 Free PMC article.
Novel working hypothesis for pathogenesis of hematological malignancies: combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD).
Kitamura T, Watanabe-Okochi N, Enomoto Y, Nakahara F, Oki T, Komeno Y, Kato N, Doki N, Uchida T, Kagiyama Y, Togami K, Kawabata KC, Nishimura K, Hayashi Y, Nagase R, Saika M, Fukushima T, Asada S, Fujino T, Izawa Y, Horikawa S, Fukuyama T, Tanaka Y, Ono R, Goyama S, Nosaka T, Kitaura J, Inoue D. Kitamura T, et al. Among authors: fukushima t. J Biochem. 2016 Jan;159(1):17-25. doi: 10.1093/jb/mvv114. Epub 2015 Nov 20. J Biochem. 2016. PMID: 26590301 Free PMC article. Review.
High expression of ABCG2 induced by EZH2 disruption has pivotal roles in MDS pathogenesis.
Kawabata KC, Hayashi Y, Inoue D, Meguro H, Sakurai H, Fukuyama T, Tanaka Y, Asada S, Fukushima T, Nagase R, Takeda R, Harada Y, Kitaura J, Goyama S, Harada H, Aburatani H, Kitamura T. Kawabata KC, et al. Among authors: fukushima t. Leukemia. 2018 Feb;32(2):419-428. doi: 10.1038/leu.2017.227. Epub 2017 Jul 19. Leukemia. 2018. PMID: 28720764
Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.
Asada S, Goyama S, Inoue D, Shikata S, Takeda R, Fukushima T, Yonezawa T, Fujino T, Hayashi Y, Kawabata KC, Fukuyama T, Tanaka Y, Yokoyama A, Yamazaki S, Kozuka-Hata H, Oyama M, Kojima S, Kawazu M, Mano H, Kitamura T. Asada S, et al. Among authors: fukushima t. Nat Commun. 2018 Jul 16;9(1):2733. doi: 10.1038/s41467-018-05085-9. Nat Commun. 2018. PMID: 30013160 Free PMC article.
Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium.
Fukushima T, Tanaka Y, Hamey FK, Chang CH, Oki T, Asada S, Hayashi Y, Fujino T, Yonezawa T, Takeda R, Kawabata KC, Fukuyama T, Umemoto T, Takubo K, Takizawa H, Goyama S, Ishihama Y, Honda H, Göttgens B, Kitamura T. Fukushima T, et al. Cell Rep. 2019 Dec 17;29(12):4144-4158.e7. doi: 10.1016/j.celrep.2019.11.061. Cell Rep. 2019. PMID: 31851939 Free article.
HHEX promotes myeloid transformation in cooperation with mutant ASXL1.
Takeda R, Asada S, Park SJ, Yokoyama A, Becker HJ, Kanai A, Visconte V, Hershberger C, Hayashi Y, Yonezawa T, Tamura M, Fukushima T, Tanaka Y, Fukuyama T, Matsumoto A, Yamasaki S, Nakai K, Yamazaki S, Inaba T, Shibata T, Inoue D, Honda H, Goyama S, Maciejewski JP, Kitamura T. Takeda R, et al. Among authors: fukushima t. Blood. 2020 Oct 1;136(14):1670-1684. doi: 10.1182/blood.2019004613. Blood. 2020. PMID: 32492700 Free article.
Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway.
Fujino T, Goyama S, Sugiura Y, Inoue D, Asada S, Yamasaki S, Matsumoto A, Yamaguchi K, Isobe Y, Tsuchiya A, Shikata S, Sato N, Morinaga H, Fukuyama T, Tanaka Y, Fukushima T, Takeda R, Yamamoto K, Honda H, Nishimura EK, Furukawa Y, Shibata T, Abdel-Wahab O, Suematsu M, Kitamura T. Fujino T, et al. Among authors: fukushima t. Nat Commun. 2021 Mar 23;12(1):1826. doi: 10.1038/s41467-021-22053-y. Nat Commun. 2021. PMID: 33758188 Free PMC article.
Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors.
Tanaka Y, Takeda R, Fukushima T, Mikami K, Tsuchiya S, Tamura M, Adachi K, Umemoto T, Asada S, Watanabe N, Morishita S, Imai M, Nagata M, Araki M, Takizawa H, Fukuyama T, Lamagna C, Masuda ES, Ito R, Goyama S, Komatsu N, Takaku T, Kitamura T. Tanaka Y, et al. Among authors: fukushima t. Nat Commun. 2022 Jan 12;13(1):271. doi: 10.1038/s41467-021-27928-8. Nat Commun. 2022. PMID: 35022428 Free PMC article.
2,546 results