Alzari PM - Search Results

1

PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.

Rieck B, Degiacomi G, Zimmermann M, Cascioferro A, Boldrin F, Lazar-Adler NR, Bottrill AR, le Chevalier F, Frigui W, Bellinzoni M, Lisa MN, Alzari PM, Nguyen L, Brosch R, Sauer U, Manganelli R, O'Hare HM. Rieck B, et al. Among authors: alzari pm. PLoS Pathog. 2017 May 17;13(5):e1006399. doi: 10.1371/journal.ppat.1006399. eCollection 2017 May. PLoS Pathog. 2017. PMID: 28545104 Free PMC article.

2

PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis.

Boitel B, Ortiz-Lombardía M, Durán R, Pompeo F, Cole ST, Cerveñansky C, Alzari PM. Boitel B, et al. Among authors: alzari pm. Mol Microbiol. 2003 Sep;49(6):1493-508. doi: 10.1046/j.1365-2958.2003.03657.x. Mol Microbiol. 2003. PMID: 12950916 Free article.

3

Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress.

Guimarães BG, Souchon H, Honoré N, Saint-Joanis B, Brosch R, Shepard W, Cole ST, Alzari PM. Guimarães BG, et al. Among authors: alzari pm. J Biol Chem. 2005 Jul 8;280(27):25735-42. doi: 10.1074/jbc.M503076200. Epub 2005 May 10. J Biol Chem. 2005. PMID: 15886207 Free article.

4

Conserved autophosphorylation pattern in activation loops and juxtamembrane regions of Mycobacterium tuberculosis Ser/Thr protein kinases.

Durán R, Villarino A, Bellinzoni M, Wehenkel A, Fernandez P, Boitel B, Cole ST, Alzari PM, Cerveñansky C. Durán R, et al. Among authors: alzari pm. Biochem Biophys Res Commun. 2005 Aug 5;333(3):858-67. doi: 10.1016/j.bbrc.2005.05.173. Biochem Biophys Res Commun. 2005. PMID: 15967413

5

Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions.

Villarino A, Duran R, Wehenkel A, Fernandez P, England P, Brodin P, Cole ST, Zimny-Arndt U, Jungblut PR, Cerveñansky C, Alzari PM. Villarino A, et al. Among authors: alzari pm. J Mol Biol. 2005 Jul 29;350(5):953-63. doi: 10.1016/j.jmb.2005.05.049. J Mol Biol. 2005. PMID: 15978616

6

The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.

Bellinzoni M, Haouz A, Graña M, Munier-Lehmann H, Shepard W, Alzari PM. Bellinzoni M, et al. Among authors: alzari pm. Protein Sci. 2006 Jun;15(6):1489-93. doi: 10.1110/ps.062163406. Epub 2006 May 2. Protein Sci. 2006. PMID: 16672241 Free PMC article.

7

The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria.

Wehenkel A, Fernandez P, Bellinzoni M, Catherinot V, Barilone N, Labesse G, Jackson M, Alzari PM. Wehenkel A, et al. Among authors: alzari pm. FEBS Lett. 2006 May 29;580(13):3018-22. doi: 10.1016/j.febslet.2006.04.046. Epub 2006 Apr 27. FEBS Lett. 2006. PMID: 16674948 Free article.

8

Insights into the catalytic mechanism of PPM Ser/Thr phosphatases from the atomic resolution structures of a mycobacterial enzyme.

Bellinzoni M, Wehenkel A, Shepard W, Alzari PM. Bellinzoni M, et al. Among authors: alzari pm. Structure. 2007 Jul;15(7):863-72. doi: 10.1016/j.str.2007.06.002. Structure. 2007. PMID: 17637345 Free article.

9

Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential.

Wehenkel A, Bellinzoni M, Graña M, Duran R, Villarino A, Fernandez P, Andre-Leroux G, England P, Takiff H, Cerveñansky C, Cole ST, Alzari PM. Wehenkel A, et al. Among authors: alzari pm. Biochim Biophys Acta. 2008 Jan;1784(1):193-202. doi: 10.1016/j.bbapap.2007.08.006. Epub 2007 Aug 14. Biochim Biophys Acta. 2008. PMID: 17869195 Review.

10

Structural and binding studies of the three-metal center in two mycobacterial PPM Ser/Thr protein phosphatases.

Wehenkel A, Bellinzoni M, Schaeffer F, Villarino A, Alzari PM. Wehenkel A, et al. Among authors: alzari pm. J Mol Biol. 2007 Dec 7;374(4):890-8. doi: 10.1016/j.jmb.2007.09.076. Epub 2007 Oct 2. J Mol Biol. 2007. PMID: 17961594

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