Helmlinger G - Search Results

1

Pharmacometric Modeling of Naloxegol Efficacy and Safety: Impact on Dose and Label.

Al-Huniti N, Zhou D, Xu H, Aksenov S, Bui KH, Fox R, Helmlinger G, Stanski D. Al-Huniti N, et al. Among authors: helmlinger g. Clin Pharmacol Ther. 2017 Nov;102(5):741-744. doi: 10.1002/cpt.719. Epub 2017 May 26. Clin Pharmacol Ther. 2017. PMID: 28548207 Review.

2

Assessing QT/QTc interval prolongation with concentration-QT modeling for Phase I studies: impact of computational platforms, model structures and confidence interval calculation methods.

Lu J, Li J, Helmlinger G, Al-Huniti N. Lu J, et al. Among authors: helmlinger g. J Pharmacokinet Pharmacodyn. 2018 Jun;45(3):469-482. doi: 10.1007/s10928-018-9582-0. Epub 2018 Mar 19. J Pharmacokinet Pharmacodyn. 2018. PMID: 29556866 Clinical Trial.

3

Integrating dose estimation into a decision-making framework for model-based drug development.

Dunyak J, Mitchell P, Hamrén B, Helmlinger G, Matcham J, Stanski D, Al-Huniti N. Dunyak J, et al. Among authors: helmlinger g. Pharm Stat. 2018 Mar;17(2):155-168. doi: 10.1002/pst.1841. Epub 2018 Jan 10. Pharm Stat. 2018. PMID: 29322659

4

Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model.

Kosinsky Y, Dovedi SJ, Peskov K, Voronova V, Chu L, Tomkinson H, Al-Huniti N, Stanski DR, Helmlinger G. Kosinsky Y, et al. Among authors: helmlinger g. J Immunother Cancer. 2018 Feb 27;6(1):17. doi: 10.1186/s40425-018-0327-9. J Immunother Cancer. 2018. PMID: 29486799 Free PMC article.

5

Drug-disease modeling in the pharmaceutical industry - where mechanistic systems pharmacology and statistical pharmacometrics meet.

Helmlinger G, Al-Huniti N, Aksenov S, Peskov K, Hallow KM, Chu L, Boulton D, Eriksson U, Hamrén B, Lambert C, Masson E, Tomkinson H, Stanski D. Helmlinger G, et al. Eur J Pharm Sci. 2017 Nov 15;109S:S39-S46. doi: 10.1016/j.ejps.2017.05.028. Epub 2017 May 12. Eur J Pharm Sci. 2017. PMID: 28506868 Review.

6

Resistance models to EGFR inhibition and chemotherapy in non-small cell lung cancer via analysis of tumour size dynamics.

Mistry HB, Helmlinger G, Al-Huniti N, Vishwanathan K, Yates J. Mistry HB, et al. Among authors: helmlinger g. Cancer Chemother Pharmacol. 2019 Jul;84(1):51-60. doi: 10.1007/s00280-019-03840-3. Epub 2019 Apr 24. Cancer Chemother Pharmacol. 2019. PMID: 31020352 Free PMC article.

7

Dose dependence of treatment-related adverse events for immune checkpoint inhibitor therapies: a model-based meta-analysis.

Shulgin B, Kosinsky Y, Omelchenko A, Chu L, Mugundu G, Aksenov S, Pimentel R, DeYulia G, Kim G, Peskov K, Helmlinger G. Shulgin B, et al. Among authors: helmlinger g. Oncoimmunology. 2020 May 21;9(1):1748982. doi: 10.1080/2162402X.2020.1748982. Oncoimmunology. 2020. PMID: 32934874 Free PMC article. Review.

8

Longitudinal Tumor Size and Neutrophil-to-Lymphocyte Ratio Are Prognostic Biomarkers for Overall Survival in Patients With Advanced Non-Small Cell Lung Cancer Treated With Durvalumab.

Gavrilov S, Zhudenkov K, Helmlinger G, Dunyak J, Peskov K, Aksenov S. Gavrilov S, et al. Among authors: helmlinger g. CPT Pharmacometrics Syst Pharmacol. 2021 Jan;10(1):67-74. doi: 10.1002/psp4.12578. Epub 2020 Dec 21. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 33319498 Free PMC article.

9

Renal Effects of Dapagliflozin in People with and without Diabetes with Moderate or Severe Renal Dysfunction: Prospective Modeling of an Ongoing Clinical Trial.

Hallow KM, Boulton DW, Penland RC, Helmlinger G, Nieves EH, van Raalte DH, Heerspink HL, Greasley PJ. Hallow KM, et al. Among authors: helmlinger g. J Pharmacol Exp Ther. 2020 Oct;375(1):76-91. doi: 10.1124/jpet.120.000040. Epub 2020 Aug 6. J Pharmacol Exp Ther. 2020. PMID: 32764153

10

An integrated approach for inference and mechanistic modeling for advancing drug development.

Aksenov SV, Church B, Dhiman A, Georgieva A, Sarangapani R, Helmlinger G, Khalil IG. Aksenov SV, et al. Among authors: helmlinger g. FEBS Lett. 2005 Mar 21;579(8):1878-83. doi: 10.1016/j.febslet.2005.02.012. FEBS Lett. 2005. PMID: 15763567 Free article. Review.

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