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Waldenstrom macroglobulinemia cells devoid of BTKC481S or CXCR4WHIM-like mutations acquire resistance to ibrutinib through upregulation of Bcl-2 and AKT resulting in vulnerability towards venetoclax or MK2206 treatment.
Paulus A, Akhtar S, Yousaf H, Manna A, Paulus SM, Bashir Y, Caulfield TR, Kuranz-Blake M, Chitta K, Wang X, Asmann Y, Hudec R, Springer W, Ailawadhi S, Chanan-Khan A. Paulus A, et al. Among authors: akhtar s. Blood Cancer J. 2017 May 26;7(5):e565. doi: 10.1038/bcj.2017.40. Blood Cancer J. 2017. PMID: 28548645 Free PMC article.
Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells.
Paulus A, Akhtar S, Caulfield TR, Samuel K, Yousaf H, Bashir Y, Paulus SM, Tran D, Hudec R, Cogen D, Jiang J, Edenfield B, Novak A, Ansell SM, Witzig T, Martin P, Coleman M, Roy V, Ailawadhi S, Chitta K, Linder S, Chanan-Khan A. Paulus A, et al. Among authors: akhtar s. Blood Cancer J. 2016 Nov 4;6(11):e492. doi: 10.1038/bcj.2016.93. Blood Cancer J. 2016. PMID: 27813535 Free PMC article.
AT-101 downregulates BCL2 and MCL1 and potentiates the cytotoxic effects of lenalidomide and dexamethasone in preclinical models of multiple myeloma and Waldenström macroglobulinaemia.
Paulus A, Chitta K, Akhtar S, Personett D, Miller KC, Thompson KJ, Carr J, Kumar S, Roy V, Ansell SM, Mikhael JR, Dispenzieri A, Reeder CB, Rivera CE, Foran J, Chanan-Khan A. Paulus A, et al. Among authors: akhtar s. Br J Haematol. 2014 Feb;164(3):352-365. doi: 10.1111/bjh.12633. Epub 2013 Nov 17. Br J Haematol. 2014. PMID: 24236538 Free PMC article.
Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells.
Chitta K, Paulus A, Akhtar S, Blake MK, Caulfield TR, Novak AJ, Ansell SM, Advani P, Ailawadhi S, Sher T, Linder S, Chanan-Khan A. Chitta K, et al. Among authors: akhtar s. Br J Haematol. 2015 May;169(3):377-90. doi: 10.1111/bjh.13304. Epub 2015 Feb 17. Br J Haematol. 2015. PMID: 25691154 Free PMC article.
Targeting CD38 with daratumumab is lethal to Waldenström macroglobulinaemia cells.
Paulus A, Manna A, Akhtar S, Paulus SM, Sharma M, Coignet MV, Jiang L, Roy V, Witzig TE, Ansell SM, Allan J, Furman R, Aulakh S, Manochakian R, Ailawadhi S, Chanan-Khan AA, Sher T. Paulus A, et al. Among authors: akhtar s. Br J Haematol. 2018 Oct;183(2):196-211. doi: 10.1111/bjh.15515. Epub 2018 Aug 6. Br J Haematol. 2018. PMID: 30080238 Free PMC article.
Targeting CD38 Enhances the Antileukemic Activity of Ibrutinib in Chronic Lymphocytic Leukemia.
Manna A, Aulakh S, Jani P, Ahmed S, Akhtar S, Coignet M, Heckman M, Meghji Z, Bhatia K, Sharma A, Sher T, Alegria V, Malavasi F, Chini EN, Chanan-Khan A, Ailawadhi S, Paulus A. Manna A, et al. Among authors: akhtar s. Clin Cancer Res. 2019 Jul 1;25(13):3974-3985. doi: 10.1158/1078-0432.CCR-18-3412. Epub 2019 Apr 2. Clin Cancer Res. 2019. PMID: 30940652 Free PMC article.
Novel tumor-targeted liposomes comprised of an MDM2 antagonist plus proteasome inhibitor display anti-tumor activity in a xenograft model of bortezomib-resistant Waldenstrom macroglobulinemia.
Madamsetty VS, Paulus A, Akhtar S, Manna A, Rachamalla HR, Banerjee R, Mukhopadhyay D, Chanan-Khan A. Madamsetty VS, et al. Among authors: akhtar s. Leuk Lymphoma. 2020 Oct;61(10):2399-2408. doi: 10.1080/10428194.2020.1775204. Epub 2020 Jun 19. Leuk Lymphoma. 2020. PMID: 32558607
1,863 results