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β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections.
Grassmé H, Henry B, Ziobro R, Becker KA, Riethmüller J, Gardner A, Seitz AP, Steinmann J, Lang S, Ward C, Schuchman EH, Caldwell CC, Kamler M, Edwards MJ, Brodlie M, Gulbins E. Grassmé H, et al. Among authors: edwards mj. Cell Host Microbe. 2017 Jun 14;21(6):707-718.e8. doi: 10.1016/j.chom.2017.05.001. Epub 2017 May 25. Cell Host Microbe. 2017. PMID: 28552668 Free PMC article.
Sphingolipids as targets for inhalation treatment of cystic fibrosis.
Becker KA, Riethmüller J, Seitz AP, Gardner A, Boudreau R, Kamler M, Kleuser B, Schuchman E, Caldwell CC, Edwards MJ, Grassmé H, Brodlie M, Gulbins E. Becker KA, et al. Among authors: edwards mj. Adv Drug Deliv Rev. 2018 Aug;133:66-75. doi: 10.1016/j.addr.2018.04.015. Epub 2018 Apr 24. Adv Drug Deliv Rev. 2018. PMID: 29698625 Review.
Sphingosine kills bacteria by binding to cardiolipin.
Verhaegh R, Becker KA, Edwards MJ, Gulbins E. Verhaegh R, et al. Among authors: edwards mj. J Biol Chem. 2020 May 29;295(22):7686-7696. doi: 10.1074/jbc.RA119.012325. Epub 2020 Apr 23. J Biol Chem. 2020. PMID: 32327486 Free PMC article.
Acid Ceramidase Rescues Cystic Fibrosis Mice from Pulmonary Infections.
Becker KA, Verhaegh R, Verhasselt HL, Keitsch S, Soddemann M, Wilker B, Wilson GC, Buer J, Ahmad SA, Edwards MJ, Gulbins E. Becker KA, et al. Among authors: edwards mj. Infect Immun. 2021 Jan 19;89(2):e00677-20. doi: 10.1128/IAI.00677-20. Print 2021 Jan 19. Infect Immun. 2021. PMID: 33139382 Free PMC article.
Ceramide mediates lung fibrosis in cystic fibrosis.
Ziobro R, Henry B, Edwards MJ, Lentsch AB, Gulbins E. Ziobro R, et al. Among authors: edwards mj. Biochem Biophys Res Commun. 2013 May 17;434(4):705-9. doi: 10.1016/j.bbrc.2013.03.032. Epub 2013 Mar 21. Biochem Biophys Res Commun. 2013. PMID: 23523785 Free PMC article.
1,044 results