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β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections.
Grassmé H, Henry B, Ziobro R, Becker KA, Riethmüller J, Gardner A, Seitz AP, Steinmann J, Lang S, Ward C, Schuchman EH, Caldwell CC, Kamler M, Edwards MJ, Brodlie M, Gulbins E. Grassmé H, et al. Among authors: schuchman eh. Cell Host Microbe. 2017 Jun 14;21(6):707-718.e8. doi: 10.1016/j.chom.2017.05.001. Epub 2017 May 25. Cell Host Microbe. 2017. PMID: 28552668 Free PMC article.
Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa.
Pewzner-Jung Y, Tavakoli Tabazavareh S, Grassmé H, Becker KA, Japtok L, Steinmann J, Joseph T, Lang S, Tuemmler B, Schuchman EH, Lentsch AB, Kleuser B, Edwards MJ, Futerman AH, Gulbins E. Pewzner-Jung Y, et al. Among authors: schuchman eh. EMBO Mol Med. 2014 Sep;6(9):1205-14. doi: 10.15252/emmm.201404075. EMBO Mol Med. 2014. PMID: 25085879 Free PMC article.
Sphingolipids as targets for inhalation treatment of cystic fibrosis.
Becker KA, Riethmüller J, Seitz AP, Gardner A, Boudreau R, Kamler M, Kleuser B, Schuchman E, Caldwell CC, Edwards MJ, Grassmé H, Brodlie M, Gulbins E. Becker KA, et al. Adv Drug Deliv Rev. 2018 Aug;133:66-75. doi: 10.1016/j.addr.2018.04.015. Epub 2018 Apr 24. Adv Drug Deliv Rev. 2018. PMID: 29698625 Review.
Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM.
Park MH, Lee JY, Park KH, Jung IK, Kim KT, Lee YS, Ryu HH, Jeong Y, Kang M, Schwaninger M, Gulbins E, Reichel M, Kornhuber J, Yamaguchi T, Kim HJ, Kim SH, Schuchman EH, Jin HK, Bae JS. Park MH, et al. Among authors: schuchman eh. Neuron. 2018 Oct 10;100(1):167-182.e9. doi: 10.1016/j.neuron.2018.09.010. Epub 2018 Sep 27. Neuron. 2018. PMID: 30269989 Free article.
Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis.
Gardner AI, Haq IJ, Simpson AJ, Becker KA, Gallagher J, Saint-Criq V, Verdon B, Mavin E, Trigg A, Gray MA, Koulman A, McDonnell MJ, Fisher AJ, Kramer EL, Clancy JP, Ward C, Schuchman EH, Gulbins E, Brodlie M. Gardner AI, et al. Among authors: schuchman eh. Am J Respir Crit Care Med. 2020 Oct 15;202(8):1133-1145. doi: 10.1164/rccm.202001-0180OC. Am J Respir Crit Care Med. 2020. PMID: 32569477 Free PMC article.
Deregulation of sphingolipid metabolism in Alzheimer's disease.
He X, Huang Y, Li B, Gong CX, Schuchman EH. He X, et al. Among authors: schuchman eh. Neurobiol Aging. 2010 Mar;31(3):398-408. doi: 10.1016/j.neurobiolaging.2008.05.010. Epub 2008 Jun 10. Neurobiol Aging. 2010. PMID: 18547682 Free PMC article.
243 results