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Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing.
Carroll B, Nelson G, Rabanal-Ruiz Y, Kucheryavenko O, Dunhill-Turner NA, Chesterman CC, Zahari Q, Zhang T, Conduit SE, Mitchell CA, Maddocks ODK, Lovat P, von Zglinicki T, Korolchuk VI. Carroll B, et al. Among authors: von zglinicki t. J Cell Biol. 2017 Jul 3;216(7):1949-1957. doi: 10.1083/jcb.201610113. Epub 2017 May 31. J Cell Biol. 2017. PMID: 28566325 Free PMC article.
Monitoring DNA damage during cell senescence.
Nelson G, von Zglinicki T. Nelson G, et al. Among authors: von zglinicki t. Methods Mol Biol. 2013;965:197-213. doi: 10.1007/978-1-62703-239-1_13. Methods Mol Biol. 2013. PMID: 23296660
Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?
Korolchuk VI, Miwa S, Carroll B, von Zglinicki T. Korolchuk VI, et al. Among authors: von zglinicki t. EBioMedicine. 2017 Jul;21:7-13. doi: 10.1016/j.ebiom.2017.03.020. Epub 2017 Mar 14. EBioMedicine. 2017. PMID: 28330601 Free PMC article. Review.
The mTORC1-autophagy pathway is a target for senescent cell elimination.
Kucheryavenko O, Nelson G, von Zglinicki T, Korolchuk VI, Carroll B. Kucheryavenko O, et al. Among authors: von zglinicki t. Biogerontology. 2019 Jun;20(3):331-335. doi: 10.1007/s10522-019-09802-9. Epub 2019 Feb 23. Biogerontology. 2019. PMID: 30798505 Free PMC article.
DNA damage foci in mitosis are devoid of 53BP1.
Nelson G, Buhmann M, von Zglinicki T. Nelson G, et al. Among authors: von zglinicki t. Cell Cycle. 2009 Oct 15;8(20):3379-83. doi: 10.4161/cc.8.20.9857. Epub 2009 Oct 19. Cell Cycle. 2009. PMID: 19806024
The bystander effect contributes to the accumulation of senescent cells in vivo.
da Silva PFL, Ogrodnik M, Kucheryavenko O, Glibert J, Miwa S, Cameron K, Ishaq A, Saretzki G, Nagaraja-Grellscheid S, Nelson G, von Zglinicki T. da Silva PFL, et al. Among authors: von zglinicki t. Aging Cell. 2019 Feb;18(1):e12848. doi: 10.1111/acel.12848. Epub 2018 Nov 21. Aging Cell. 2019. PMID: 30462359 Free PMC article.
A senescent cell bystander effect: senescence-induced senescence.
Nelson G, Wordsworth J, Wang C, Jurk D, Lawless C, Martin-Ruiz C, von Zglinicki T. Nelson G, et al. Among authors: von zglinicki t. Aging Cell. 2012 Apr;11(2):345-9. doi: 10.1111/j.1474-9726.2012.00795.x. Epub 2012 Feb 9. Aging Cell. 2012. PMID: 22321662 Free PMC article.
249 results