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17,367 results

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Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2.
Iwatani-Yoshihara M, Ito M, Klein MG, Yamamoto T, Yonemori K, Tanaka T, Miwa M, Morishita D, Endo S, Tjhen R, Qin L, Nakanishi A, Maezaki H, Kawamoto T. Iwatani-Yoshihara M, et al. Among authors: yamamoto t. J Med Chem. 2017 Jul 13;60(13):5759-5771. doi: 10.1021/acs.jmedchem.7b00461. Epub 2017 Jun 20. J Med Chem. 2017. PMID: 28586220
Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design.
Yasui T, Yamamoto T, Sakai N, Asano K, Takai T, Yoshitomi Y, Davis M, Takagi T, Sakamoto K, Sogabe S, Kamada Y, Lane W, Snell G, Iwata M, Goto M, Inooka H, Sakamoto JI, Nakada Y, Imaeda Y. Yasui T, et al. Among authors: yamamoto t. Bioorg Med Chem. 2017 Sep 1;25(17):4876-4886. doi: 10.1016/j.bmc.2017.07.037. Epub 2017 Jul 20. Bioorg Med Chem. 2017. PMID: 28760529
Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore.
Tanaka Y, Seto M, Kakegawa K, Takami K, Kikuchi F, Yamamoto T, Nakamura M, Daini M, Murakami M, Ohashi T, Kasahara T, Wang J, Ikeda Z, Wada Y, Puenner F, Fujii T, Inazuka M, Sato S, Suzaki T, Oak JH, Takai Y, Kohara H, Kimoto K, Oki H, Mikami S, Sasaki M, Tanaka Y. Tanaka Y, et al. Among authors: yamamoto t. J Med Chem. 2022 Mar 10;65(5):4270-4290. doi: 10.1021/acs.jmedchem.1c02078. Epub 2022 Feb 21. J Med Chem. 2022. PMID: 35188773 Free article.
Synthesis and structure-activity relationships of 5,6,7,8-tetrahydropyrido[3,4-b]pyrazine-based hydroxamic acids as HB-EGF shedding inhibitors.
Yoshiizumi K, Yamamoto M, Miyasaka T, Ito Y, Kumihara H, Sawa M, Kiyoi T, Yamamoto T, Nakajima F, Hirayama R, Kondo H, Ishibushi E, Ohmoto H, Inoue Y, Yoshino K. Yoshiizumi K, et al. Among authors: yamamoto m, yamamoto t. Bioorg Med Chem. 2003 Feb 6;11(3):433-50. doi: 10.1016/s0968-0896(02)00426-1. Bioorg Med Chem. 2003. PMID: 12517439
A Novel Orally Available Delta-5 Desaturase Inhibitor Prevents Atherosclerotic Lesions Accompanied by Changes in Fatty Acid Composition and Eicosanoid Production in ApoE Knockout Mice.
Takagahara S, Shinohara H, Itokawa S, Satomi Y, Ando A, Yamamoto T, Suzuki H, Fujimoto T, Kubo K, Ikeda S. Takagahara S, et al. Among authors: yamamoto t. J Pharmacol Exp Ther. 2019 Nov;371(2):290-298. doi: 10.1124/jpet.119.259846. Epub 2019 Sep 5. J Pharmacol Exp Ther. 2019. PMID: 31488602
17,367 results
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