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HTLV-I infection of WE17/10 CD4+ cell line leads to progressive alteration of Ca2+ influx that eventually results in loss of CD7 expression and activation of an antiapoptotic pathway involving AKT and BAD which paves the way for malignant transformation.
Akl H, Badran BM, Zein NE, Bex F, Sotiriou C, Willard-Gallo KE, Burny A, Martiat P. Akl H, et al. Among authors: zein ne. Leukemia. 2007 Apr;21(4):788-96. doi: 10.1038/sj.leu.2404585. Epub 2007 Feb 8. Leukemia. 2007. PMID: 17287851