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Gel-forming mucins form distinct morphologic structures in airways.
Ostedgaard LS, Moninger TO, McMenimen JD, Sawin NM, Parker CP, Thornell IM, Powers LS, Gansemer ND, Bouzek DC, Cook DP, Meyerholz DK, Abou Alaiwa MH, Stoltz DA, Welsh MJ. Ostedgaard LS, et al. Among authors: thornell im. Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6842-6847. doi: 10.1073/pnas.1703228114. Epub 2017 Jun 12. Proc Natl Acad Sci U S A. 2017. PMID: 28607090 Free PMC article.
Electrolyte transport properties in distal small airways from cystic fibrosis pigs with implications for host defense.
Li X, Tang XX, Vargas Buonfiglio LG, Comellas AP, Thornell IM, Ramachandran S, Karp PH, Taft PJ, Sheets K, Abou Alaiwa MH, Welsh MJ, Meyerholz DK, Stoltz DA, Zabner J. Li X, et al. Among authors: thornell im. Am J Physiol Lung Cell Mol Physiol. 2016 Apr 1;310(7):L670-9. doi: 10.1152/ajplung.00422.2015. Epub 2016 Jan 22. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 26801568 Free PMC article.
Motile cilia of human airway epithelia contain hedgehog signaling components that mediate noncanonical hedgehog signaling.
Mao S, Shah AS, Moninger TO, Ostedgaard LS, Lu L, Tang XX, Thornell IM, Reznikov LR, Ernst SE, Karp PH, Tan P, Keshavjee S, Abou Alaiwa MH, Welsh MJ. Mao S, et al. Among authors: thornell im. Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):1370-1375. doi: 10.1073/pnas.1719177115. Epub 2018 Jan 22. Proc Natl Acad Sci U S A. 2018. PMID: 29358407 Free PMC article.
Widespread airway distribution and short-term phenotypic correction of cystic fibrosis pigs following aerosol delivery of piggyBac/adenovirus.
Cooney AL, Singh BK, Loza LM, Thornell IM, Hippee CE, Powers LS, Ostedgaard LS, Meyerholz DK, Wohlford-Lenane C, Stoltz DA, B McCray P Jr, Sinn PL. Cooney AL, et al. Among authors: thornell im. Nucleic Acids Res. 2018 Oct 12;46(18):9591-9600. doi: 10.1093/nar/gky773. Nucleic Acids Res. 2018. PMID: 30165523 Free PMC article.
A Novel AAV-mediated Gene Delivery System Corrects CFTR Function in Pigs.
Cooney AL, Thornell IM, Singh BK, Shah VS, Stoltz DA, McCray PB Jr, Zabner J, Sinn PL. Cooney AL, et al. Among authors: thornell im. Am J Respir Cell Mol Biol. 2019 Dec;61(6):747-754. doi: 10.1165/rcmb.2019-0006OC. Am J Respir Cell Mol Biol. 2019. PMID: 31184507 Free PMC article.
TNFα and IL-17 alkalinize airway surface liquid through CFTR and pendrin.
Rehman T, Thornell IM, Pezzulo AA, Thurman AL, Romano Ibarra GS, Karp PH, Tan P, Duffey ME, Welsh MJ. Rehman T, et al. Among authors: thornell im. Am J Physiol Cell Physiol. 2020 Aug 1;319(2):C331-C344. doi: 10.1152/ajpcell.00112.2020. Epub 2020 May 20. Am J Physiol Cell Physiol. 2020. PMID: 32432926 Free PMC article.
Early pathogenesis of cystic fibrosis gallbladder disease in a porcine model.
Zarei K, Stroik MR, Gansemer ND, Thurman AL, Ostedgaard LS, Ernst SE, Thornell IM, Powers LS, Pezzulo AA, Meyerholz DK, Stoltz DA. Zarei K, et al. Among authors: thornell im. Lab Invest. 2020 Nov;100(11):1388-1399. doi: 10.1038/s41374-020-0474-8. Epub 2020 Jul 27. Lab Invest. 2020. PMID: 32719544 Free PMC article.
31 results