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Epigallocatechin-3-gallate and related phenol compounds redirect the amyloidogenic aggregation pathway of ataxin-3 towards non-toxic aggregates and prevent toxicity in neural cells and Caenorhabditis elegans animal model.
Visentin C, Pellistri F, Natalello A, Vertemara J, Bonanomi M, Gatta E, Penco A, Relini A, De Gioia L, Airoldi C, Regonesi ME, Tortora P. Visentin C, et al. Among authors: airoldi c. Hum Mol Genet. 2017 Sep 1;26(17):3271-3284. doi: 10.1093/hmg/ddx211. Hum Mol Genet. 2017. PMID: 28633380
Selective cytotoxicity of a bicyclic Ras inhibitor in cancer cells expressing K-Ras(G13D).
Palmioli A, Sacco E, Airoldi C, Di Nicolantonio F, D'Urzo A, Shirasawa S, Sasazuki T, Di Domizio A, De Gioia L, Martegani E, Bardelli A, Peri F, Vanoni M. Palmioli A, et al. Among authors: airoldi c. Biochem Biophys Res Commun. 2009 Sep 4;386(4):593-7. doi: 10.1016/j.bbrc.2009.06.069. Epub 2009 Jun 18. Biochem Biophys Res Commun. 2009. PMID: 19540195 Free article.
Structure-activity studies on arylamides and arysulfonamides Ras inhibitors.
Colombo S, Palmioli A, Airoldi C, Tisi R, Fantinato S, Olivieri S, De Gioia L, Martegani E, Peri F. Colombo S, et al. Among authors: airoldi c. Curr Cancer Drug Targets. 2010 Mar;10(2):192-9. doi: 10.2174/156800910791054185. Curr Cancer Drug Targets. 2010. PMID: 20088786
The Multi-Level Mechanism of Action of a Pan-Ras Inhibitor Explains its Antiproliferative Activity on Cetuximab-Resistant Cancer Cells.
Tisi R, Spinelli M, Palmioli A, Airoldi C, Cazzaniga P, Besozzi D, Nobile MS, Mazzoleni E, Arnhold S, De Gioia L, Grandori R, Peri F, Vanoni M, Sacco E. Tisi R, et al. Among authors: airoldi c. Front Mol Biosci. 2021 Feb 17;8:625979. doi: 10.3389/fmolb.2021.625979. eCollection 2021. Front Mol Biosci. 2021. PMID: 33681292 Free PMC article.
268 results