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Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression.
Westerlund I, Shi Y, Toskas K, Fell SM, Li S, Surova O, Södersten E, Kogner P, Nyman U, Schlisio S, Holmberg J. Westerlund I, et al. Among authors: holmberg j. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6137-E6146. doi: 10.1073/pnas.1700655114. Epub 2017 Jul 10. Proc Natl Acad Sci U S A. 2017. PMID: 28696319 Free PMC article.
Aberrant splicing in neuroblastoma generates RNA-fusion transcripts and provides vulnerability to spliceosome inhibitors.
Shi Y, Yuan J, Rraklli V, Maxymovitz E, Cipullo M, Liu M, Li S, Westerlund I, Bedoya-Reina OC, Bullova P, Rorbach J, Juhlin CC, Stenman A, Larsson C, Kogner P, O'Sullivan MJ, Schlisio S, Holmberg J. Shi Y, et al. Among authors: holmberg j. Nucleic Acids Res. 2021 Mar 18;49(5):2509-2521. doi: 10.1093/nar/gkab054. Nucleic Acids Res. 2021. PMID: 33555349 Free PMC article.
Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors.
Bedoya-Reina OC, Li W, Arceo M, Plescher M, Bullova P, Pui H, Kaucka M, Kharchenko P, Martinsson T, Holmberg J, Adameyko I, Deng Q, Larsson C, Juhlin CC, Kogner P, Schlisio S. Bedoya-Reina OC, et al. Among authors: holmberg j. Nat Commun. 2021 Sep 7;12(1):5309. doi: 10.1038/s41467-021-24870-7. Nat Commun. 2021. PMID: 34493726 Free PMC article.
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance.
Li S, Rodriguez J, Li W, Bullova P, Fell SM, Surova O, Westerlund I, Topcic D, Bergsland M, Stenman A, Muhr J, Nistér M, Holmberg J, Juhlin CC, Larsson C, von Kriegsheim A, Kaelin WG Jr, Schlisio S. Li S, et al. Among authors: holmberg j. Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16997-17006. doi: 10.1073/pnas.1900748116. Epub 2019 Aug 2. Proc Natl Acad Sci U S A. 2019. PMID: 31375625 Free PMC article.
Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome.
Li S, Li W, Yuan J, Bullova P, Wu J, Zhang X, Liu Y, Plescher M, Rodriguez J, Bedoya-Reina OC, Jannig PR, Valente-Silva P, Yu M, Henriksson MA, Zubarev RA, Smed-Sörensen A, Suzuki CK, Ruas JL, Holmberg J, Larsson C, Christofer Juhlin C, von Kriegsheim A, Cao Y, Schlisio S. Li S, et al. Among authors: holmberg j. Nat Metab. 2022 Oct;4(10):1421. doi: 10.1038/s42255-022-00651-4. Nat Metab. 2022. PMID: 36076077 Free PMC article. No abstract available.
287 results