Lenz O - Search Results

1

Antiviral profiling of the capsid assembly modulator BAY41-4109 on full-length HBV genotype A-H clinical isolates and core site-directed mutants in vitro.

Berke JM, Tan Y, Verbinnen T, Dehertogh P, Vergauwen K, Vos A, Lenz O, Pauwels F. Berke JM, et al. Among authors: lenz o. Antiviral Res. 2017 Aug;144:205-215. doi: 10.1016/j.antiviral.2017.06.016. Epub 2017 Jun 21. Antiviral Res. 2017. PMID: 28647474

2

In Vitro Activity of Simeprevir against Hepatitis C Virus Genotype 1 Clinical Isolates and Its Correlation with NS3 Sequence and Site-Directed Mutants.

Verbinnen T, Fevery B, Vijgen L, Jacobs T, De Meyer S, Lenz O. Verbinnen T, et al. Among authors: lenz o. Antimicrob Agents Chemother. 2015 Dec;59(12):7548-57. doi: 10.1128/AAC.01444-15. Epub 2015 Sep 21. Antimicrob Agents Chemother. 2015. PMID: 26392483 Free PMC article.

3

Anti-HBV activity of the HBV capsid assembly modulator JNJ-56136379 across full-length genotype A-H clinical isolates and core site-directed mutants in vitro.

Verbinnen T, Tan Y, Wang G, Dehertogh P, Vergauwen K, Neefs JM, Jacoby E, Lenz O, Berke JM. Verbinnen T, et al. Among authors: lenz o. J Antimicrob Chemother. 2020 Sep 1;75(9):2526-2534. doi: 10.1093/jac/dkaa179. J Antimicrob Chemother. 2020. PMID: 32417895

4

Virology analyses of HCV genotype 4 isolates from patients treated with simeprevir and peginterferon/ribavirin in the Phase III RESTORE study.

Fevery B, Verbinnen T, Peeters M, Janssen K, Witek J, Jessner W, De Meyer S, Lenz O. Fevery B, et al. Among authors: lenz o. J Viral Hepat. 2017 Jan;24(1):28-36. doi: 10.1111/jvh.12614. Epub 2016 Oct 3. J Viral Hepat. 2017. PMID: 27696653 Clinical Trial.

5

Development of a high-content screening assay to identify compounds interfering with the formation of the hepatitis C virus replication complex.

Berke JM, Fenistein D, Pauwels F, Bobbaers R, Lenz O, Lin TI, Krausz E, Fanning G. Berke JM, et al. Among authors: lenz o. J Virol Methods. 2010 May;165(2):268-76. doi: 10.1016/j.jviromet.2010.02.007. Epub 2010 Feb 11. J Virol Methods. 2010. PMID: 20153373

6

In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435.

Lenz O, Verbinnen T, Lin TI, Vijgen L, Cummings MD, Lindberg J, Berke JM, Dehertogh P, Fransen E, Scholliers A, Vermeiren K, Ivens T, Raboisson P, Edlund M, Storm S, Vrang L, de Kock H, Fanning GC, Simmen KA. Lenz O, et al. Antimicrob Agents Chemother. 2010 May;54(5):1878-87. doi: 10.1128/AAC.01452-09. Epub 2010 Feb 22. Antimicrob Agents Chemother. 2010. PMID: 20176898 Free PMC article.

7

Replication capacity of minority variants in viral populations can affect the assessment of resistance in HCV chimeric replicon phenotyping assays.

Verbinnen T, Jacobs T, Vijgen L, Ceulemans H, Neyts J, Fanning G, Lenz O. Verbinnen T, et al. Among authors: lenz o. J Antimicrob Chemother. 2012 Oct;67(10):2327-37. doi: 10.1093/jac/dks234. Epub 2012 Jun 21. J Antimicrob Chemother. 2012. PMID: 22723600

8

Virologic response and characterisation of HCV genotype 2-6 in patients receiving TMC435 monotherapy (study TMC435-C202).

Lenz O, Vijgen L, Berke JM, Cummings MD, Fevery B, Peeters M, De Smedt G, Moreno C, Picchio G. Lenz O, et al. J Hepatol. 2013 Mar;58(3):445-51. doi: 10.1016/j.jhep.2012.10.028. Epub 2012 Nov 7. J Hepatol. 2013. PMID: 23142061

9

Prevalence of the hepatitis C virus NS3 polymorphism Q80K in genotype 1 patients in the European region.

Sarrazin C, Lathouwers E, Peeters M, Daems B, Buelens A, Witek J, Wyckmans Y, Fevery B, Verbinnen T, Ghys A, Schlag M, Baldini A, De Meyer S, Lenz O. Sarrazin C, et al. Among authors: lenz o. Antiviral Res. 2015 Apr;116:10-6. doi: 10.1016/j.antiviral.2015.01.003. Epub 2015 Jan 19. Antiviral Res. 2015. PMID: 25614456 Free article.

10

Effect of Plasma Protein Binding on the Anti-Hepatitis B Virus Activity and Pharmacokinetic Properties of NVR 3-778.

Helsen N, Vervoort T, Vandenbossche J, Lenz O, Monshouwer M, Pauwels F, Snoeys J. Helsen N, et al. Among authors: lenz o. Antimicrob Agents Chemother. 2018 Oct 24;62(11):e01497-18. doi: 10.1128/AAC.01497-18. Print 2018 Nov. Antimicrob Agents Chemother. 2018. PMID: 30181376 Free PMC article.

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