Knowles TPJ - Search Results

1

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.

Iljina M, Hong L, Horrocks MH, Ludtmann MH, Choi ML, Hughes CD, Ruggeri FS, Guilliams T, Buell AK, Lee JE, Gandhi S, Lee SF, Bryant CE, Vendruscolo M, Knowles TPJ, Dobson CM, De Genst E, Klenerman D. Iljina M, et al. Among authors: knowles tpj. BMC Biol. 2017 Jul 3;15(1):57. doi: 10.1186/s12915-017-0390-6. BMC Biol. 2017. PMID: 28673288 Free PMC article.

2

The component polypeptide chains of bovine insulin nucleate or inhibit aggregation of the parent protein in a conformation-dependent manner.

Devlin GL, Knowles TP, Squires A, McCammon MG, Gras SL, Nilsson MR, Robinson CV, Dobson CM, MacPhee CE. Devlin GL, et al. J Mol Biol. 2006 Jul 7;360(2):497-509. doi: 10.1016/j.jmb.2006.05.007. Epub 2006 May 17. J Mol Biol. 2006. PMID: 16774767

3

Spatial persistence of angular correlations in amyloid fibrils.

Knowles TP, Smith JF, Craig A, Dobson CM, Welland ME. Knowles TP, et al. Phys Rev Lett. 2006 Jun 16;96(23):238301. doi: 10.1103/PhysRevLett.96.238301. Epub 2006 Jun 12. Phys Rev Lett. 2006. PMID: 16803412

4

Characterization of the nanoscale properties of individual amyloid fibrils.

Smith JF, Knowles TP, Dobson CM, Macphee CE, Welland ME. Smith JF, et al. Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15806-11. doi: 10.1073/pnas.0604035103. Epub 2006 Oct 12. Proc Natl Acad Sci U S A. 2006. PMID: 17038504 Free PMC article.

5

Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass.

Knowles TP, Shu W, Devlin GL, Meehan S, Auer S, Dobson CM, Welland ME. Knowles TP, et al. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10016-21. doi: 10.1073/pnas.0610659104. Epub 2007 May 31. Proc Natl Acad Sci U S A. 2007. PMID: 17540728 Free PMC article.

6

Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alphaA-, alphaB- and R120G alphaB-crystallins.

Meehan S, Knowles TP, Baldwin AJ, Smith JF, Squires AM, Clements P, Treweek TM, Ecroyd H, Tartaglia GG, Vendruscolo M, Macphee CE, Dobson CM, Carver JA. Meehan S, et al. J Mol Biol. 2007 Sep 14;372(2):470-84. doi: 10.1016/j.jmb.2007.06.060. Epub 2007 Jun 29. J Mol Biol. 2007. PMID: 17662998

7

Measurement of amyloid fibril length distributions by inclusion of rotational motion in solution NMR diffusion measurements.

Baldwin AJ, Anthony-Cahill SJ, Knowles TP, Lippens G, Christodoulou J, Barker PD, Dobson CM. Baldwin AJ, et al. Angew Chem Int Ed Engl. 2008;47(18):3385-7. doi: 10.1002/anie.200703915. Angew Chem Int Ed Engl. 2008. PMID: 18350531 No abstract available.

8

Position-dependent electrostatic protection against protein aggregation.

Buell AK, Tartaglia GG, Birkett NR, Waudby CA, Vendruscolo M, Salvatella X, Welland ME, Dobson CM, Knowles TP. Buell AK, et al. Chembiochem. 2009 May 25;10(8):1309-12. doi: 10.1002/cbic.200900144. Chembiochem. 2009. PMID: 19415709

9

Biosensor-based label-free assays of amyloid growth.

White DA, Buell AK, Dobson CM, Welland ME, Knowles TP. White DA, et al. FEBS Lett. 2009 Aug 20;583(16):2587-92. doi: 10.1016/j.febslet.2009.06.008. Epub 2009 Jun 11. FEBS Lett. 2009. PMID: 19523953 Free article. Review.

10

Imaging amyloid fibrils within cells using a Se-labelling strategy.

Porter AE, Knowles TP, Muller K, Meehan S, McGuire E, Skepper J, Welland ME, Dobson CM. Porter AE, et al. J Mol Biol. 2009 Oct 2;392(4):868-71. doi: 10.1016/j.jmb.2009.07.061. Epub 2009 Jul 25. J Mol Biol. 2009. PMID: 19635483

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