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Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.
Iljina M, Hong L, Horrocks MH, Ludtmann MH, Choi ML, Hughes CD, Ruggeri FS, Guilliams T, Buell AK, Lee JE, Gandhi S, Lee SF, Bryant CE, Vendruscolo M, Knowles TPJ, Dobson CM, De Genst E, Klenerman D. Iljina M, et al. Among authors: lee je, lee sf. BMC Biol. 2017 Jul 3;15(1):57. doi: 10.1186/s12915-017-0390-6. BMC Biol. 2017. PMID: 28673288 Free PMC article.
Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping.
Bongiovanni MN, Godet J, Horrocks MH, Tosatto L, Carr AR, Wirthensohn DC, Ranasinghe RT, Lee JE, Ponjavic A, Fritz JV, Dobson CM, Klenerman D, Lee SF. Bongiovanni MN, et al. Among authors: lee je, lee sf. Nat Commun. 2016 Dec 8;7:13544. doi: 10.1038/ncomms13544. Nat Commun. 2016. PMID: 27929085 Free PMC article.
Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale.
Lee JE, Sang JC, Rodrigues M, Carr AR, Horrocks MH, De S, Bongiovanni MN, Flagmeier P, Dobson CM, Wales DJ, Lee SF, Klenerman D. Lee JE, et al. Among authors: lee sf. Nano Lett. 2018 Dec 12;18(12):7494-7501. doi: 10.1021/acs.nanolett.8b02916. Epub 2018 Nov 7. Nano Lett. 2018. PMID: 30380895 Free PMC article.
Structure-specific amyloid precipitation in biofluids.
Rodrigues M, Bhattacharjee P, Brinkmalm A, Do DT, Pearson CM, De S, Ponjavic A, Varela JA, Kulenkampff K, Baudrexel I, Emin D, Ruggeri FS, Lee JE, Carr AR, Knowles TPJ, Zetterberg H, Snaddon TN, Gandhi S, Lee SF, Klenerman D. Rodrigues M, et al. Among authors: lee je, lee sf. Nat Chem. 2022 Sep;14(9):1045-1053. doi: 10.1038/s41557-022-00976-3. Epub 2022 Jul 7. Nat Chem. 2022. PMID: 35798951 Free article.
Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates.
Saleeb RS, Leighton C, Lee JE, O'Shaughnessy J, Jeacock K, Chappard A, Cumberland R, Zhao T, Ball SR, Sunde M, Clarke DJ, Piché K, McPhail JA, Louwrier A, Angers R, Gandhi S, Downey P, Kunath T, Horrocks MH. Saleeb RS, et al. Among authors: lee je. Sci Adv. 2023 Nov 17;9(46):eadi7359. doi: 10.1126/sciadv.adi7359. Epub 2023 Nov 15. Sci Adv. 2023. PMID: 37967183 Free PMC article.
Single-Molecule Two-Color Coincidence Detection of Unlabeled alpha-Synuclein Aggregates.
Chappard A, Leighton C, Saleeb RS, Jeacock K, Ball SR, Morris K, Kantelberg O, Lee JE, Zacco E, Pastore A, Sunde M, Clarke DJ, Downey P, Kunath T, Horrocks MH. Chappard A, et al. Among authors: lee je. Angew Chem Weinheim Bergstr Ger. 2023 Apr 3;135(15):e202216771. doi: 10.1002/ange.202216771. Epub 2023 Feb 28. Angew Chem Weinheim Bergstr Ger. 2023. PMID: 38516037 Free PMC article.
Synaptic oligomeric tau in Alzheimer's disease - A potential culprit in the spread of tau pathology through the brain.
Colom-Cadena M, Davies C, Sirisi S, Lee JE, Simzer EM, Tzioras M, Querol-Vilaseca M, Sánchez-Aced É, Chang YY, Holt K, McGeachan RI, Rose J, Tulloch J, Wilkins L, Smith C, Andrian T, Belbin O, Pujals S, Horrocks MH, Lleó A, Spires-Jones TL. Colom-Cadena M, et al. Among authors: lee je. Neuron. 2023 Jul 19;111(14):2170-2183.e6. doi: 10.1016/j.neuron.2023.04.020. Epub 2023 May 15. Neuron. 2023. PMID: 37192625 Free article.
Single-molecule imaging of DNA gyrase activity in living Escherichia coli.
Stracy M, Wollman AJM, Kaja E, Gapinski J, Lee JE, Leek VA, McKie SJ, Mitchenall LA, Maxwell A, Sherratt DJ, Leake MC, Zawadzki P. Stracy M, et al. Among authors: lee je. Nucleic Acids Res. 2019 Jan 10;47(1):210-220. doi: 10.1093/nar/gky1143. Nucleic Acids Res. 2019. PMID: 30445553 Free PMC article.
5,242 results