MacLennan DH - Search Results

1

Reduced threshold for store overload-induced Ca²⁺ release is a common defect of RyR1 mutations associated with malignant hyperthermia and central core disease.

Chen W, Koop A, Liu Y, Guo W, Wei J, Wang R, MacLennan DH, Dirksen RT, Chen SRW. Chen W, et al. Among authors: maclennan dh. Biochem J. 2017 Aug 7;474(16):2749-2761. doi: 10.1042/BCJ20170282. Biochem J. 2017. PMID: 28687594 Free PMC article.

2

The role of the calcium release channel of skeletal muscle sarcoplasmic reticulum in malignant hyperthermia.

MacLennan DH, Chen SR. MacLennan DH, et al. Ann N Y Acad Sci. 1993 Dec 20;707:294-304. doi: 10.1111/j.1749-6632.1993.tb38060.x. Ann N Y Acad Sci. 1993. PMID: 9137560 Review.

3

Role of the sequence surrounding predicted transmembrane helix M4 in membrane association and function of the Ca(2+) release channel of skeletal muscle sarcoplasmic reticulum (ryanodine receptor isoform 1).

Du GG, Avila G, Sharma P, Khanna VK, Dirksen RT, MacLennan DH. Du GG, et al. Among authors: maclennan dh. J Biol Chem. 2004 Sep 3;279(36):37566-74. doi: 10.1074/jbc.M406637200. Epub 2004 Jun 28. J Biol Chem. 2004. PMID: 15226293 Free article.

4

Muscle weakness in Ryr1I4895T/WT knock-in mice as a result of reduced ryanodine receptor Ca2+ ion permeation and release from the sarcoplasmic reticulum.

Loy RE, Orynbayev M, Xu L, Andronache Z, Apostol S, Zvaritch E, MacLennan DH, Meissner G, Melzer W, Dirksen RT. Loy RE, et al. Among authors: maclennan dh. J Gen Physiol. 2011 Jan;137(1):43-57. doi: 10.1085/jgp.201010523. Epub 2010 Dec 13. J Gen Physiol. 2011. PMID: 21149547 Free PMC article.

5

Novel excitation-contraction uncoupled RYR1 mutations in patients with central core disease.

Kraeva N, Zvaritch E, Rossi AE, Goonasekera SA, Zaid H, Frodis W, Kraev A, Dirksen RT, Maclennan DH, Riazi S. Kraeva N, et al. Among authors: maclennan dh. Neuromuscul Disord. 2013 Feb;23(2):120-32. doi: 10.1016/j.nmd.2012.08.007. Epub 2012 Nov 24. Neuromuscul Disord. 2013. PMID: 23183335 Free PMC article.

6

Identification of calmodulin-, Ca(2+)-, and ruthenium red-binding domains in the Ca2+ release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum.

Chen SR, MacLennan DH. Chen SR, et al. Among authors: maclennan dh. J Biol Chem. 1994 Sep 9;269(36):22698-704. J Biol Chem. 1994. PMID: 7521330 Free article.

7

Asymmetrical blockade of the Ca2+ release channel (ryanodine receptor) by 12-kDa FK506 binding protein.

Chen SR, Zhang L, MacLennan DH. Chen SR, et al. Among authors: maclennan dh. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11953-7. doi: 10.1073/pnas.91.25.11953. Proc Natl Acad Sci U S A. 1994. PMID: 7527548 Free PMC article.

8

Antibodies as probes for Ca2+ activation sites in the Ca2+ release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum.

Chen SR, Zhang L, MacLennan DH. Chen SR, et al. Among authors: maclennan dh. J Biol Chem. 1993 Jun 25;268(18):13414-21. J Biol Chem. 1993. PMID: 7685761 Free article.

9

HEK-293 cells possess a carbachol- and thapsigargin-sensitive intracellular Ca2+ store that is responsive to stop-flow medium changes and insensitive to caffeine and ryanodine.

Tong J, Du GG, Chen SR, MacLennan DH. Tong J, et al. Among authors: maclennan dh. Biochem J. 1999 Oct 1;343 Pt 1(Pt 1):39-44. Biochem J. 1999. PMID: 10493909 Free PMC article.

10

Central core disease mutations R4892W, I4897T and G4898E in the ryanodine receptor isoform 1 reduce the Ca2+ sensitivity and amplitude of Ca2+-dependent Ca2+ release.

Du GG, Khanna VK, Guo X, MacLennan DH. Du GG, et al. Among authors: maclennan dh. Biochem J. 2004 Sep 1;382(Pt 2):557-64. doi: 10.1042/BJ20040580. Biochem J. 2004. PMID: 15175001 Free PMC article.

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