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Organic chemistry. Nanomole-scale high-throughput chemistry for the synthesis of complex molecules.
Buitrago Santanilla A, Regalado EL, Pereira T, Shevlin M, Bateman K, Campeau LC, Schneeweis J, Berritt S, Shi ZC, Nantermet P, Liu Y, Helmy R, Welch CJ, Vachal P, Davies IW, Cernak T, Dreher SD. Buitrago Santanilla A, et al. Among authors: davies iw. Science. 2015 Jan 2;347(6217):49-53. doi: 10.1126/science.1259203. Epub 2014 Nov 20. Science. 2015. PMID: 25554781
Aryl amination using ligand-free Ni(II) salts and photoredox catalysis.
Corcoran EB, Pirnot MT, Lin S, Dreher SD, DiRocco DA, Davies IW, Buchwald SL, MacMillan DW. Corcoran EB, et al. Among authors: davies iw. Science. 2016 Jul 15;353(6296):279-83. doi: 10.1126/science.aag0209. Epub 2016 Jun 23. Science. 2016. PMID: 27338703 Free PMC article.
Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench-Stable Organozinc Reagents.
Greshock TJ, Moore KP, McClain RT, Bellomo A, Chung CK, Dreher SD, Kutchukian PS, Peng Z, Davies IW, Vachal P, Ellwart M, Manolikakes SM, Knochel P, Nantermet PG. Greshock TJ, et al. Among authors: davies iw. Angew Chem Int Ed Engl. 2016 Oct 24;55(44):13714-13718. doi: 10.1002/anie.201604652. Epub 2016 Sep 30. Angew Chem Int Ed Engl. 2016. PMID: 27690172
Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery.
Pipal RW, Stout KT, Musacchio PZ, Ren S, Graham TJA, Verhoog S, Gantert L, Lohith TG, Schmitz A, Lee HS, Hesk D, Hostetler ED, Davies IW, MacMillan DWC. Pipal RW, et al. Among authors: davies iw. Nature. 2021 Jan;589(7843):542-547. doi: 10.1038/s41586-020-3015-0. Epub 2020 Nov 25. Nature. 2021. PMID: 33238289 Free PMC article.
126 results