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Page 1
Crystal structure of CO-bound cytochrome c oxidase determined by serial femtosecond X-ray crystallography at room temperature.
Ishigami I, Zatsepin NA, Hikita M, Conrad CE, Nelson G, Coe JD, Basu S, Grant TD, Seaberg MH, Sierra RG, Hunter MS, Fromme P, Fromme R, Yeh SR, Rousseau DL. Ishigami I, et al. Among authors: seaberg mh. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8011-8016. doi: 10.1073/pnas.1705628114. Epub 2017 Jul 11. Proc Natl Acad Sci U S A. 2017. PMID: 28698372 Free PMC article.
Chromophore twisting in the excited state of a photoswitchable fluorescent protein captured by time-resolved serial femtosecond crystallography.
Coquelle N, Sliwa M, Woodhouse J, Schirò G, Adam V, Aquila A, Barends TRM, Boutet S, Byrdin M, Carbajo S, De la Mora E, Doak RB, Feliks M, Fieschi F, Foucar L, Guillon V, Hilpert M, Hunter MS, Jakobs S, Koglin JE, Kovacsova G, Lane TJ, Lévy B, Liang M, Nass K, Ridard J, Robinson JS, Roome CM, Ruckebusch C, Seaberg M, Thepaut M, Cammarata M, Demachy I, Field M, Shoeman RL, Bourgeois D, Colletier JP, Schlichting I, Weik M. Coquelle N, et al. Nat Chem. 2018 Jan;10(1):31-37. doi: 10.1038/nchem.2853. Epub 2017 Sep 11. Nat Chem. 2018. PMID: 29256511
Enzyme intermediates captured "on the fly" by mix-and-inject serial crystallography.
Olmos JL Jr, Pandey S, Martin-Garcia JM, Calvey G, Katz A, Knoska J, Kupitz C, Hunter MS, Liang M, Oberthuer D, Yefanov O, Wiedorn M, Heyman M, Holl M, Pande K, Barty A, Miller MD, Stern S, Roy-Chowdhury S, Coe J, Nagaratnam N, Zook J, Verburgt J, Norwood T, Poudyal I, Xu D, Koglin J, Seaberg MH, Zhao Y, Bajt S, Grant T, Mariani V, Nelson G, Subramanian G, Bae E, Fromme R, Fung R, Schwander P, Frank M, White TA, Weierstall U, Zatsepin N, Spence J, Fromme P, Chapman HN, Pollack L, Tremblay L, Ourmazd A, Phillips GN Jr, Schmidt M. Olmos JL Jr, et al. Among authors: seaberg mh. BMC Biol. 2018 May 31;16(1):59. doi: 10.1186/s12915-018-0524-5. BMC Biol. 2018. PMID: 29848358 Free PMC article.
Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser.
Nogly P, Weinert T, James D, Carbajo S, Ozerov D, Furrer A, Gashi D, Borin V, Skopintsev P, Jaeger K, Nass K, Båth P, Bosman R, Koglin J, Seaberg M, Lane T, Kekilli D, Brünle S, Tanaka T, Wu W, Milne C, White T, Barty A, Weierstall U, Panneels V, Nango E, Iwata S, Hunter M, Schapiro I, Schertler G, Neutze R, Standfuss J. Nogly P, et al. Science. 2018 Jul 13;361(6398):eaat0094. doi: 10.1126/science.aat0094. Epub 2018 Jun 14. Science. 2018. PMID: 29903883
Aminoglycoside ribosome interactions reveal novel conformational states at ambient temperature.
O'Sullivan ME, Poitevin F, Sierra RG, Gati C, Dao EH, Rao Y, Aksit F, Ciftci H, Corsepius N, Greenhouse R, Hayes B, Hunter MS, Liang M, McGurk A, Mbgam P, Obrinsky T, Pardo-Avila F, Seaberg MH, Cheng AG, Ricci AJ, DeMirci H. O'Sullivan ME, et al. Among authors: seaberg mh. Nucleic Acids Res. 2018 Oct 12;46(18):9793-9804. doi: 10.1093/nar/gky693. Nucleic Acids Res. 2018. PMID: 30113694 Free PMC article.
Structure of the 30S ribosomal decoding complex at ambient temperature.
Dao EH, Poitevin F, Sierra RG, Gati C, Rao Y, Ciftci HI, Akşit F, McGurk A, Obrinski T, Mgbam P, Hayes B, De Lichtenberg C, Pardo-Avila F, Corsepius N, Zhang L, Seaberg MH, Hunter MS, Liang M, Koglin JE, Wakatsuki S, Demirci H. Dao EH, et al. Among authors: seaberg mh. RNA. 2018 Dec;24(12):1667-1676. doi: 10.1261/rna.067660.118. Epub 2018 Aug 23. RNA. 2018. PMID: 30139800 Free PMC article.
The Macromolecular Femtosecond Crystallography Instrument at the Linac Coherent Light Source.
Sierra RG, Batyuk A, Sun Z, Aquila A, Hunter MS, Lane TJ, Liang M, Yoon CH, Alonso-Mori R, Armenta R, Castagna JC, Hollenbeck M, Osier TO, Hayes M, Aldrich J, Curtis R, Koglin JE, Rendahl T, Rodriguez E, Carbajo S, Guillet S, Paul R, Hart P, Nakahara K, Carini G, DeMirci H, Dao EH, Hayes BM, Rao YP, Chollet M, Feng Y, Fuller FD, Kupitz C, Sato T, Seaberg MH, Song S, van Driel TB, Yavas H, Zhu D, Cohen AE, Wakatsuki S, Boutet S. Sierra RG, et al. Among authors: seaberg mh. J Synchrotron Radiat. 2019 Mar 1;26(Pt 2):346-357. doi: 10.1107/S1600577519001577. Epub 2019 Feb 22. J Synchrotron Radiat. 2019. PMID: 30855242 Free PMC article.
Near-physiological-temperature serial crystallography reveals conformations of SARS-CoV-2 main protease active site for improved drug repurposing.
Durdagi S, Dağ Ç, Dogan B, Yigin M, Avsar T, Buyukdag C, Erol I, Ertem FB, Calis S, Yildirim G, Orhan MD, Guven O, Aksoydan B, Destan E, Sahin K, Besler SO, Oktay L, Shafiei A, Tolu I, Ayan E, Yuksel B, Peksen AB, Gocenler O, Yucel AD, Can O, Ozabrahamyan S, Olkan A, Erdemoglu E, Aksit F, Tanisali G, Yefanov OM, Barty A, Tolstikova A, Ketawala GK, Botha S, Dao EH, Hayes B, Liang M, Seaberg MH, Hunter MS, Batyuk A, Mariani V, Su Z, Poitevin F, Yoon CH, Kupitz C, Sierra RG, Snell EH, DeMirci H. Durdagi S, et al. Among authors: seaberg mh. Structure. 2021 Dec 2;29(12):1382-1396.e6. doi: 10.1016/j.str.2021.07.007. Epub 2021 Aug 16. Structure. 2021. PMID: 34403647 Free PMC article.
Cooperative allostery and structural dynamics of streptavidin at cryogenic- and ambient-temperature.
Ayan E, Yuksel B, Destan E, Ertem FB, Yildirim G, Eren M, Yefanov OM, Barty A, Tolstikova A, Ketawala GK, Botha S, Dao EH, Hayes B, Liang M, Seaberg MH, Hunter MS, Batyuk A, Mariani V, Su Z, Poitevin F, Yoon CH, Kupitz C, Cohen A, Doukov T, Sierra RG, Dağ Ç, DeMirci H. Ayan E, et al. Among authors: seaberg mh. Commun Biol. 2022 Jan 20;5(1):73. doi: 10.1038/s42003-021-02903-7. Commun Biol. 2022. PMID: 35058563 Free PMC article.
Detection of a geminate photoproduct of bovine cytochrome c oxidase by time-resolved serial femtosecond crystallography.
Ishigami I, Carbajo S, Zatsepin N, Hikita M, Conrad CE, Nelson G, Coe J, Basu S, Grant T, Seaberg MH, Sierra RG, Hunter MS, Fromme P, Fromme R, Rousseau DL, Yeh SR. Ishigami I, et al. Among authors: seaberg mh. bioRxiv [Preprint]. 2023 May 10:2023.05.08.539888. doi: 10.1101/2023.05.08.539888. bioRxiv. 2023. Update in: J Am Chem Soc. 2023 Oct 18;145(41):22305-22309. doi: 10.1021/jacs.3c07803 PMID: 37214971 Free PMC article. Updated. Preprint.
38 results