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Strategic Targeting of Multiple BMP Receptors Prevents Trauma-Induced Heterotopic Ossification.
Agarwal S, Loder SJ, Breuler C, Li J, Cholok D, Brownley C, Peterson J, Hsieh HH, Drake J, Ranganathan K, Niknafs YS, Xiao W, Li S, Kumar R, Tompkins R, Longaker MT, Davis TA, Yu PB, Mishina Y, Levi B. Agarwal S, et al. Among authors: yu pb. Mol Ther. 2017 Aug 2;25(8):1974-1987. doi: 10.1016/j.ymthe.2017.01.008. Epub 2017 Jul 15. Mol Ther. 2017. PMID: 28716575 Free PMC article.
BMP type I receptor inhibition reduces heterotopic [corrected] ossification.
Yu PB, Deng DY, Lai CS, Hong CC, Cuny GD, Bouxsein ML, Hong DW, McManus PM, Katagiri T, Sachidanandan C, Kamiya N, Fukuda T, Mishina Y, Peterson RT, Bloch KD. Yu PB, et al. Nat Med. 2008 Dec;14(12):1363-9. doi: 10.1038/nm.1888. Epub 2008 Nov 30. Nat Med. 2008. PMID: 19029982 Free PMC article.
Development of an ALK2-biased BMP type I receptor kinase inhibitor.
Mohedas AH, Xing X, Armstrong KA, Bullock AN, Cuny GD, Yu PB. Mohedas AH, et al. Among authors: yu pb. ACS Chem Biol. 2013;8(6):1291-302. doi: 10.1021/cb300655w. Epub 2013 Apr 30. ACS Chem Biol. 2013. PMID: 23547776 Free PMC article.
Constitutively active ALK2 receptor mutants require type II receptor cooperation.
Bagarova J, Vonner AJ, Armstrong KA, Börgermann J, Lai CS, Deng DY, Beppu H, Alfano I, Filippakopoulos P, Morrell NW, Bullock AN, Knaus P, Mishina Y, Yu PB. Bagarova J, et al. Among authors: yu pb. Mol Cell Biol. 2013 Jun;33(12):2413-24. doi: 10.1128/MCB.01595-12. Epub 2013 Apr 9. Mol Cell Biol. 2013. PMID: 23572558 Free PMC article.
Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency.
Malhotra R, Burke MF, Martyn T, Shakartzi HR, Thayer TE, O'Rourke C, Li P, Derwall M, Spagnolli E, Kolodziej SA, Hoeft K, Mayeur C, Jiramongkolchai P, Kumar R, Buys ES, Yu PB, Bloch KD, Bloch DB. Malhotra R, et al. Among authors: yu pb. PLoS One. 2015 Jan 20;10(1):e0117098. doi: 10.1371/journal.pone.0117098. eCollection 2015. PLoS One. 2015. PMID: 25603410 Free PMC article.
Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification.
Dey D, Bagarova J, Hatsell SJ, Armstrong KA, Huang L, Ermann J, Vonner AJ, Shen Y, Mohedas AH, Lee A, Eekhoff EM, van Schie A, Demay MB, Keller C, Wagers AJ, Economides AN, Yu PB. Dey D, et al. Among authors: yu pb. Sci Transl Med. 2016 Nov 23;8(366):366ra163. doi: 10.1126/scitranslmed.aaf1090. Sci Transl Med. 2016. PMID: 27881824 Free PMC article.
The traumatic bone: trauma-induced heterotopic ossification.
Dey D, Wheatley BM, Cholok D, Agarwal S, Yu PB, Levi B, Davis TA. Dey D, et al. Among authors: yu pb. Transl Res. 2017 Aug;186:95-111. doi: 10.1016/j.trsl.2017.06.004. Epub 2017 Jun 15. Transl Res. 2017. PMID: 28668522 Free PMC article. Review.
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