Orr A - Search Results

1

Sec17/Sec18 act twice, enhancing membrane fusion and then disassembling cis-SNARE complexes.

Song H, Orr A, Duan M, Merz AJ, Wickner W. Song H, et al. Among authors: orr a. Elife. 2017 Jul 18;6:e26646. doi: 10.7554/eLife.26646. Elife. 2017. PMID: 28718762 Free PMC article.

2

Membranes linked by trans-SNARE complexes require lipids prone to non-bilayer structure for progression to fusion.

Zick M, Stroupe C, Orr A, Douville D, Wickner WT. Zick M, et al. Among authors: orr a. Elife. 2014 Jan 1;3:e01879. doi: 10.7554/eLife.01879. Elife. 2014. PMID: 24596153 Free PMC article.

3

Yeast vacuolar HOPS, regulated by its kinase, exploits affinities for acidic lipids and Rab:GTP for membrane binding and to catalyze tethering and fusion.

Orr A, Wickner W, Rusin SF, Kettenbach AN, Zick M. Orr A, et al. Mol Biol Cell. 2015 Jan 15;26(2):305-15. doi: 10.1091/mbc.E14-08-1298. Epub 2014 Nov 19. Mol Biol Cell. 2015. PMID: 25411340 Free PMC article.

4

Sec17 can trigger fusion of trans-SNARE paired membranes without Sec18.

Zick M, Orr A, Schwartz ML, Merz AJ, Wickner WT. Zick M, et al. Among authors: orr a. Proc Natl Acad Sci U S A. 2015 May 5;112(18):E2290-7. doi: 10.1073/pnas.1506409112. Epub 2015 Apr 20. Proc Natl Acad Sci U S A. 2015. PMID: 25902545 Free PMC article.

5

Correction: Membranes linked by trans-SNARE complexes require lipids prone to non-bilayer structure for progression to fusion.

Zick M, Stroupe C, Orr A, Douville D, Wickner WT. Zick M, et al. Among authors: orr a. Elife. 2015 May 27;4:e08843. doi: 10.7554/eLife.08843. Elife. 2015. PMID: 26012539 Free PMC article. No abstract available.

6

HOPS catalyzes the interdependent assembly of each vacuolar SNARE into a SNARE complex.

Orr A, Song H, Rusin SF, Kettenbach AN, Wickner W. Orr A, et al. Mol Biol Cell. 2017 Apr 1;28(7):975-983. doi: 10.1091/mbc.E16-10-0743. Epub 2017 Feb 1. Mol Biol Cell. 2017. PMID: 28148647 Free PMC article.

7

HOPS recognizes each SNARE, assembling ternary trans-complexes for rapid fusion upon engagement with the 4th SNARE.

Song H, Orr AS, Lee M, Harner ME, Wickner WT. Song H, et al. Elife. 2020 Jan 21;9:e53559. doi: 10.7554/eLife.53559. Elife. 2020. PMID: 31961324 Free PMC article.

8

Sec17/Sec18 can support membrane fusion without help from completion of SNARE zippering.

Song H, Torng TL, Orr AS, Brunger AT, Wickner WT. Song H, et al. Elife. 2021 May 4;10:e67578. doi: 10.7554/eLife.67578. Elife. 2021. PMID: 33944780 Free PMC article.

9

Fusion with wild-type SNARE domains is controlled by juxtamembrane domains, transmembrane anchors, and Sec17.

Orr A, Song H, Wickner W. Orr A, et al. Mol Biol Cell. 2022 May 1;33(5):ar38. doi: 10.1091/mbc.E21-11-0583. Epub 2022 Feb 16. Mol Biol Cell. 2022. PMID: 35171720 Free PMC article.

10

Sec18 supports membrane fusion by promoting Sec17 membrane association.

Orr A, Wickner W. Orr A, et al. Mol Biol Cell. 2022 Nov 1;33(13):ar127. doi: 10.1091/mbc.E22-07-0274. Epub 2022 Sep 14. Mol Biol Cell. 2022. PMID: 36103252 Free PMC article.

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