Smalley KSM - Search Results

1

BRAF Inhibitors Amplify the Proapoptotic Activity of MEK Inhibitors by Inducing ER Stress in NRAS-Mutant Melanoma.

Niessner H, Sinnberg T, Kosnopfel C, Smalley KSM, Beck D, Praetorius C, Mai M, Beissert S, Kulms D, Schaller M, Garbe C, Flaherty KT, Westphal D, Wanke I, Meier F. Niessner H, et al. Among authors: smalley ksm. Clin Cancer Res. 2017 Oct 15;23(20):6203-6214. doi: 10.1158/1078-0432.CCR-17-0098. Epub 2017 Jul 19. Clin Cancer Res. 2017. PMID: 28724666 Free PMC article.

2

The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma.

Meier F, Schittek B, Busch S, Garbe C, Smalley K, Satyamoorthy K, Li G, Herlyn M. Meier F, et al. Front Biosci. 2005 Sep 1;10:2986-3001. doi: 10.2741/1755. Front Biosci. 2005. PMID: 15970553 Review.

3

Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases.

Smalley KS, Haass NK, Brafford PA, Lioni M, Flaherty KT, Herlyn M. Smalley KS, et al. Mol Cancer Ther. 2006 May;5(5):1136-44. doi: 10.1158/1535-7163.MCT-06-0084. Mol Cancer Ther. 2006. PMID: 16731745

4

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.

King AJ, Patrick DR, Batorsky RS, Ho ML, Do HT, Zhang SY, Kumar R, Rusnak DW, Takle AK, Wilson DM, Hugger E, Wang L, Karreth F, Lougheed JC, Lee J, Chau D, Stout TJ, May EW, Rominger CM, Schaber MD, Luo L, Lakdawala AS, Adams JL, Contractor RG, Smalley KS, Herlyn M, Morrissey MM, Tuveson DA, Huang PS. King AJ, et al. Cancer Res. 2006 Dec 1;66(23):11100-5. doi: 10.1158/0008-5472.CAN-06-2554. Cancer Res. 2006. PMID: 17145850

5

An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells.

Smalley KS, Contractor R, Haass NK, Kulp AN, Atilla-Gokcumen GE, Williams DS, Bregman H, Flaherty KT, Soengas MS, Meggers E, Herlyn M. Smalley KS, et al. Cancer Res. 2007 Jan 1;67(1):209-17. doi: 10.1158/0008-5472.CAN-06-1538. Cancer Res. 2007. PMID: 17210701

6

Ki67 expression levels are a better marker of reduced melanoma growth following MEK inhibitor treatment than phospho-ERK levels.

Smalley KS, Contractor R, Haass NK, Lee JT, Nathanson KL, Medina CA, Flaherty KT, Herlyn M. Smalley KS, et al. Br J Cancer. 2007 Feb 12;96(3):445-9. doi: 10.1038/sj.bjc.6603596. Epub 2007 Jan 23. Br J Cancer. 2007. PMID: 17245336 Free PMC article.

7

Is ERK activation a good biomarker for estradiol and tamoxifen effects?

Smalley KS, Flaherty KT. Smalley KS, et al. Cancer Biol Ther. 2007 Jan;6(1):119-20. doi: 10.4161/cbt.6.1.3824. Cancer Biol Ther. 2007. PMID: 17264668 Free article. No abstract available.

8

Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.

Smalley KS, Contractor R, Nguyen TK, Xiao M, Edwards R, Muthusamy V, King AJ, Flaherty KT, Bosenberg M, Herlyn M, Nathanson KL. Smalley KS, et al. Cancer Res. 2008 Jul 15;68(14):5743-52. doi: 10.1158/0008-5472.CAN-08-0235. Cancer Res. 2008. PMID: 18632627 Free PMC article.

9

Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas.

Smalley KS, Lioni M, Dalla Palma M, Xiao M, Desai B, Egyhazi S, Hansson J, Wu H, King AJ, Van Belle P, Elder DE, Flaherty KT, Herlyn M, Nathanson KL. Smalley KS, et al. Mol Cancer Ther. 2008 Sep;7(9):2876-83. doi: 10.1158/1535-7163.MCT-08-0431. Mol Cancer Ther. 2008. PMID: 18790768 Free PMC article.

10

CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations.

Smalley KS, Xiao M, Villanueva J, Nguyen TK, Flaherty KT, Letrero R, Van Belle P, Elder DE, Wang Y, Nathanson KL, Herlyn M. Smalley KS, et al. Oncogene. 2009 Jan 8;28(1):85-94. doi: 10.1038/onc.2008.362. Epub 2008 Sep 15. Oncogene. 2009. PMID: 18794803 Free PMC article.

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