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Whole-genome sequencing revealed novel prognostic biomarkers and promising targets for therapy of ovarian clear cell carcinoma.
Itamochi H, Oishi T, Oumi N, Takeuchi S, Yoshihara K, Mikami M, Yaegashi N, Terao Y, Takehara K, Ushijima K, Watari H, Aoki D, Kimura T, Nakamura T, Yokoyama Y, Kigawa J, Sugiyama T. Itamochi H, et al. Among authors: kimura t. Br J Cancer. 2017 Aug 22;117(5):717-724. doi: 10.1038/bjc.2017.228. Epub 2017 Jul 20. Br J Cancer. 2017. PMID: 28728166 Free PMC article.
mTOR is a promising therapeutic target both in cisplatin-sensitive and cisplatin-resistant clear cell carcinoma of the ovary.
Mabuchi S, Kawase C, Altomare DA, Morishige K, Sawada K, Hayashi M, Tsujimoto M, Yamoto M, Klein-Szanto AJ, Schilder RJ, Ohmichi M, Testa JR, Kimura T. Mabuchi S, et al. Among authors: kimura t. Clin Cancer Res. 2009 Sep 1;15(17):5404-13. doi: 10.1158/1078-0432.CCR-09-0365. Epub 2009 Aug 18. Clin Cancer Res. 2009. PMID: 19690197 Free PMC article.
Aldosterone stimulates the proliferation of uterine leiomyoma cells.
Isobe A, Takeda T, Wakabayashi A, Tsuiji K, Li B, Sakata M, Yaegashi N, Kimura T. Isobe A, et al. Among authors: kimura t. Gynecol Endocrinol. 2010 May;26(5):372-7. doi: 10.3109/09513590903511521. Gynecol Endocrinol. 2010. PMID: 20050763 Free article.
Antiproliferative effect of adiponectin on rat uterine leiomyoma ELT-3 cells.
Wakabayashi A, Takeda T, Tsuiji K, Li B, Sakata M, Morishige K, Yaegashi N, Kimura T. Wakabayashi A, et al. Among authors: kimura t. Gynecol Endocrinol. 2011 Jan;27(1):33-8. doi: 10.3109/09513590.2010.487605. Epub 2010 May 26. Gynecol Endocrinol. 2011. PMID: 20504099 Free article.
Vascular endothelial growth factor is a promising therapeutic target for the treatment of clear cell carcinoma of the ovary.
Mabuchi S, Kawase C, Altomare DA, Morishige K, Hayashi M, Sawada K, Ito K, Terai Y, Nishio Y, Klein-Szanto AJ, Burger RA, Ohmichi M, Testa JR, Kimura T. Mabuchi S, et al. Among authors: kimura t. Mol Cancer Ther. 2010 Aug;9(8):2411-22. doi: 10.1158/1535-7163.MCT-10-0169. Epub 2010 Jul 27. Mol Cancer Ther. 2010. PMID: 20663925 Free PMC article.
Inhibitory effect of curcumin on uterine leiomyoma cell proliferation.
Tsuiji K, Takeda T, Li B, Wakabayashi A, Kondo A, Kimura T, Yaegashi N. Tsuiji K, et al. Among authors: kimura t. Gynecol Endocrinol. 2011 Jul;27(7):512-7. doi: 10.3109/09513590.2010.507287. Epub 2010 Jul 30. Gynecol Endocrinol. 2011. PMID: 20672906 Free article.
High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by downregulation of antigen presentation pathway.
Yoshihara K, Tsunoda T, Shigemizu D, Fujiwara H, Hatae M, Fujiwara H, Masuzaki H, Katabuchi H, Kawakami Y, Okamoto A, Nogawa T, Matsumura N, Udagawa Y, Saito T, Itamochi H, Takano M, Miyagi E, Sudo T, Ushijima K, Iwase H, Seki H, Terao Y, Enomoto T, Mikami M, Akazawa K, Tsuda H, Moriya T, Tajima A, Inoue I, Tanaka K; Japanese Serous Ovarian Cancer Study Group. Yoshihara K, et al. Clin Cancer Res. 2012 Mar 1;18(5):1374-85. doi: 10.1158/1078-0432.CCR-11-2725. Epub 2012 Jan 12. Clin Cancer Res. 2012. PMID: 22241791
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