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Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm.
Cerrone M, Montnach J, Lin X, Zhao YT, Zhang M, Agullo-Pascual E, Leo-Macias A, Alvarado FJ, Dolgalev I, Karathanos TV, Malkani K, Van Opbergen CJM, van Bavel JJA, Yang HQ, Vasquez C, Tester D, Fowler S, Liang F, Rothenberg E, Heguy A, Morley GE, Coetzee WA, Trayanova NA, Ackerman MJ, van Veen TAB, Valdivia HH, Delmar M. Cerrone M, et al. Among authors: van bavel jja, van veen tab, van opbergen cjm. Nat Commun. 2017 Jul 24;8(1):106. doi: 10.1038/s41467-017-00127-0. Nat Commun. 2017. PMID: 28740174 Free PMC article.
Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice.
Jansen JA, Noorman M, Musa H, Stein M, de Jong S, van der Nagel R, Hund TJ, Mohler PJ, Vos MA, van Veen TA, de Bakker JM, Delmar M, van Rijen HV. Jansen JA, et al. Heart Rhythm. 2012 Apr;9(4):600-7. doi: 10.1016/j.hrthm.2011.11.025. Epub 2011 Nov 16. Heart Rhythm. 2012. PMID: 22100711 Free PMC article.
Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy.
Noorman M, Hakim S, Kessler E, Groeneweg JA, Cox MG, Asimaki A, van Rijen HV, van Stuijvenberg L, Chkourko H, van der Heyden MA, Vos MA, de Jonge N, van der Smagt JJ, Dooijes D, Vink A, de Weger RA, Varro A, de Bakker JM, Saffitz JE, Hund TJ, Mohler PJ, Delmar M, Hauer RN, van Veen TA. Noorman M, et al. Heart Rhythm. 2013 Mar;10(3):412-9. doi: 10.1016/j.hrthm.2012.11.018. Epub 2012 Nov 23. Heart Rhythm. 2013. PMID: 23178689 Free PMC article.
Multilevel analyses of SCN5A mutations in arrhythmogenic right ventricular dysplasia/cardiomyopathy suggest non-canonical mechanisms for disease pathogenesis.
Te Riele AS, Agullo-Pascual E, James CA, Leo-Macias A, Cerrone M, Zhang M, Lin X, Lin B, Sobreira NL, Amat-Alarcon N, Marsman RF, Murray B, Tichnell C, van der Heijden JF, Dooijes D, van Veen TA, Tandri H, Fowler SJ, Hauer RN, Tomaselli G, van den Berg MP, Taylor MR, Brun F, Sinagra G, Wilde AA, Mestroni L, Bezzina CR, Calkins H, Peter van Tintelen J, Bu L, Delmar M, Judge DP. Te Riele AS, et al. Cardiovasc Res. 2017 Jan;113(1):102-111. doi: 10.1093/cvr/cvw234. Cardiovasc Res. 2017. PMID: 28069705 Free PMC article.
Cardiac Ca2+ signalling in zebrafish: Translation of findings to man.
van Opbergen CJM, van der Voorn SM, Vos MA, de Boer TP, van Veen TAB. van Opbergen CJM, et al. Among authors: van veen tab, van der voorn sm. Prog Biophys Mol Biol. 2018 Oct;138:45-58. doi: 10.1016/j.pbiomolbio.2018.05.002. Epub 2018 May 7. Prog Biophys Mol Biol. 2018. PMID: 29746887 Review.
Flotillins in the intercalated disc are potential modulators of cardiac excitability.
Kessler EL, van Stuijvenberg L, van Bavel JJA, van Bennekom J, Zwartsen A, Rivaud MR, Vink A, Efimov IR, Postma AV, van Tintelen JP, Remme CA, Vos MA, Banning A, de Boer TP, Tikkanen R, van Veen TAB. Kessler EL, et al. Among authors: van bavel jja, van veen tab, van stuijvenberg l, van bennekom j, van tintelen jp. J Mol Cell Cardiol. 2019 Jan;126:86-95. doi: 10.1016/j.yjmcc.2018.11.007. Epub 2018 Nov 17. J Mol Cell Cardiol. 2019. PMID: 30452906
167 results