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Neuronal Cholesterol Accumulation Induced by Cyp46a1 Down-Regulation in Mouse Hippocampus Disrupts Brain Lipid Homeostasis.
Ayciriex S, Djelti F, Alves S, Regazzetti A, Gaudin M, Varin J, Langui D, Bièche I, Hudry E, Dargère D, Aubourg P, Auzeil N, Laprévote O, Cartier N. Ayciriex S, et al. Among authors: laprevote o. Front Mol Neurosci. 2017 Jul 11;10:211. doi: 10.3389/fnmol.2017.00211. eCollection 2017. Front Mol Neurosci. 2017. PMID: 28744197 Free PMC article.
CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease.
Djelti F, Braudeau J, Hudry E, Dhenain M, Varin J, Bièche I, Marquer C, Chali F, Ayciriex S, Auzeil N, Alves S, Langui D, Potier MC, Laprevote O, Vidaud M, Duyckaerts C, Miles R, Aubourg P, Cartier N. Djelti F, et al. Among authors: laprevote o. Brain. 2015 Aug;138(Pt 8):2383-98. doi: 10.1093/brain/awv166. Epub 2015 Jul 2. Brain. 2015. PMID: 26141492
Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology.
Burlot MA, Braudeau J, Michaelsen-Preusse K, Potier B, Ayciriex S, Varin J, Gautier B, Djelti F, Audrain M, Dauphinot L, Fernandez-Gomez FJ, Caillierez R, Laprévote O, Bièche I, Auzeil N, Potier MC, Dutar P, Korte M, Buée L, Blum D, Cartier N. Burlot MA, et al. Among authors: laprevote o. Hum Mol Genet. 2015 Nov 1;24(21):5965-76. doi: 10.1093/hmg/ddv268. Epub 2015 Sep 10. Hum Mol Genet. 2015. PMID: 26358780
Ceramides and sphingomyelinases in senile plaques.
Panchal M, Gaudin M, Lazar AN, Salvati E, Rivals I, Ayciriex S, Dauphinot L, Dargère D, Auzeil N, Masserini M, Laprévote O, Duyckaerts C. Panchal M, et al. Among authors: laprevote o. Neurobiol Dis. 2014 May;65:193-201. doi: 10.1016/j.nbd.2014.01.010. Epub 2014 Jan 28. Neurobiol Dis. 2014. PMID: 24486621
172 results