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The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia.
Niederkorn M, Ishikawa C, M Hueneman K, Bartram J, Stepanchick E, R Bennett J, E Culver-Cochran A, Bolanos LC, Uible E, Choi K, Wunderlich M, Perentesis JP, M Chlon T, Filippi MD, Starczynowski DT. Niederkorn M, et al. Among authors: stepanchick e. Leukemia. 2022 Feb;36(2):438-451. doi: 10.1038/s41375-021-01394-z. Epub 2021 Aug 31. Leukemia. 2022. PMID: 34465865 Free PMC article.
Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia.
Chlon TM, Stepanchick E, Hershberger CE, Daniels NJ, Hueneman KM, Kuenzi Davis A, Choi K, Zheng Y, Gurnari C, Haferlach T, Padgett RA, Maciejewski JP, Starczynowski DT. Chlon TM, et al. Among authors: stepanchick e. Cell Stem Cell. 2021 Nov 4;28(11):1966-1981.e6. doi: 10.1016/j.stem.2021.08.004. Epub 2021 Sep 1. Cell Stem Cell. 2021. PMID: 34473945 Free PMC article.