Glioma-initiating cells retain their tumorigenicity through integration of the Sox axis and Oct4 protein.
Ikushima H, Todo T, Ino Y, Takahashi M, Saito N, Miyazawa K, Miyazono K.
Ikushima H, et al. Among authors: todo t.
J Biol Chem. 2011 Dec 2;286(48):41434-41441. doi: 10.1074/jbc.M111.300863. Epub 2011 Oct 10.
J Biol Chem. 2011.
PMID: 21987575
Free PMC article.
We have previously reported that the transforming growth factor-beta (TGF-beta)-Sox4-Sox2 pathway is essential for glioma-initiating cells to retain their stemness, and inhibition of TGF-beta signaling may lead to differentiation of glioma-initiating cells (Ikushima, H., Todo …
We have previously reported that the transforming growth factor-beta (TGF-beta)-Sox4-Sox2 pathway is essential for glioma-initiating cells t …