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Page 1
Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity.
Washburn N, Schwab I, Ortiz D, Bhatnagar N, Lansing JC, Medeiros A, Tyler S, Mekala D, Cochran E, Sarvaiya H, Garofalo K, Meccariello R, Meador JW 3rd, Rutitzky L, Schultes BC, Ling L, Avery W, Nimmerjahn F, Manning AM, Kaundinya GV, Bosques CJ. Washburn N, et al. Among authors: bosques cj. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1297-306. doi: 10.1073/pnas.1422481112. Epub 2015 Mar 2. Proc Natl Acad Sci U S A. 2015. PMID: 25733881 Free PMC article.
A single glycan on IgE is indispensable for initiation of anaphylaxis.
Shade KT, Platzer B, Washburn N, Mani V, Bartsch YC, Conroy M, Pagan JD, Bosques C, Mempel TR, Fiebiger E, Anthony RM. Shade KT, et al. J Exp Med. 2015 Apr 6;212(4):457-67. doi: 10.1084/jem.20142182. Epub 2015 Mar 30. J Exp Med. 2015. PMID: 25824821 Free PMC article.
Elucidating the interplay between IgG-Fc valency and FcγR activation for the design of immune complex inhibitors.
Ortiz DF, Lansing JC, Rutitzky L, Kurtagic E, Prod'homme T, Choudhury A, Washburn N, Bhatnagar N, Beneduce C, Holte K, Prenovitz R, Child M, Killough J, Tyler S, Brown J, Nguyen S, Schwab I, Hains M, Meccariello R, Markowitz L, Wang J, Zouaoui R, Simpson A, Schultes B, Capila I, Ling L, Nimmerjahn F, Manning AM, Bosques CJ. Ortiz DF, et al. Among authors: bosques cj. Sci Transl Med. 2016 Nov 16;8(365):365ra158. doi: 10.1126/scitranslmed.aaf9418. Sci Transl Med. 2016. PMID: 27856797
Characterization of Endogenous Human FcγRIII by Mass Spectrometry Reveals Site, Allele and Sequence Specific Glycosylation.
Washburn N, Meccariello R, Duffner J, Getchell K, Holte K, Prod'homme T, Srinivasan K, Prenovitz R, Lansing J, Capila I, Kaundinya G, Manning AM, Bosques CJ. Washburn N, et al. Among authors: bosques cj. Mol Cell Proteomics. 2019 Mar;18(3):534-545. doi: 10.1074/mcp.RA118.001142. Epub 2018 Dec 17. Mol Cell Proteomics. 2019. PMID: 30559323 Free PMC article.
Anti-inflammatory Activity of IgG-Fc.
Beneduce C, Kurtagic E, Bosques CJ. Beneduce C, et al. Among authors: bosques cj. Curr Top Microbiol Immunol. 2019;423:35-62. doi: 10.1007/82_2019_148. Curr Top Microbiol Immunol. 2019. PMID: 30790077 Review.
Circulating Markers of Inflammation Persist in Children and Adults With Giant Aneurysms After Kawasaki Disease.
Lech M, Guess J, Duffner J, Oyamada J, Shimizu C, Hoshino S, Farutin V, Bulik DA, Gutierrez B, Sarvaiya H, Kapoor B, Koppes L, Saldova R, Stockmann H, Albrecht S, McManus C, Rudd PM, Kaundinya GV, Manning AM, Bosques CJ, Kahn AM, Daniels LB, Gordon JB, Tremoulet AH, Capila I, Gunay NS, Ling LE, Burns JC. Lech M, et al. Among authors: bosques cj. Circ Genom Precis Med. 2019 Apr;12(4):e002433. doi: 10.1161/CIRCGEN.118.002433. Epub 2019 Mar 7. Circ Genom Precis Med. 2019. PMID: 30844302
[No title available]
[No authors listed] [No authors listed] PMID: 33431127
24 results