Horton JD - Search Results

1

Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.

Kim CW, Addy C, Kusunoki J, Anderson NN, Deja S, Fu X, Burgess SC, Li C, Ruddy M, Chakravarthy M, Previs S, Milstein S, Fitzgerald K, Kelley DE, Horton JD. Kim CW, et al. Among authors: horton jd. Cell Metab. 2017 Aug 1;26(2):394-406.e6. doi: 10.1016/j.cmet.2017.07.009. Cell Metab. 2017. PMID: 28768177 Free PMC article.

2

Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL.

Horton JD, Shimano H, Hamilton RL, Brown MS, Goldstein JL. Horton JD, et al. J Clin Invest. 1999 Apr;103(7):1067-76. doi: 10.1172/JCI6246. J Clin Invest. 1999. PMID: 10194480 Free PMC article.

3

Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c.

Liang G, Yang J, Horton JD, Hammer RE, Goldstein JL, Brown MS. Liang G, et al. Among authors: horton jd. J Biol Chem. 2002 Mar 15;277(11):9520-8. doi: 10.1074/jbc.M111421200. Epub 2002 Jan 8. J Biol Chem. 2002. PMID: 11782483 Free article.

4

Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice.

Vasandani C, Kafrouni AI, Caronna A, Bashmakov Y, Gotthardt M, Horton JD, Spady DK. Vasandani C, et al. Among authors: horton jd. J Lipid Res. 2002 May;43(5):772-84. J Lipid Res. 2002. PMID: 11971949 Free article.

5

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes.

Horton JD, Shah NA, Warrington JA, Anderson NN, Park SW, Brown MS, Goldstein JL. Horton JD, et al. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12027-32. doi: 10.1073/pnas.1534923100. Epub 2003 Sep 25. Proc Natl Acad Sci U S A. 2003. PMID: 14512514 Free PMC article.

6

Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.

Engelking LJ, Kuriyama H, Hammer RE, Horton JD, Brown MS, Goldstein JL, Liang G. Engelking LJ, et al. Among authors: horton jd. J Clin Invest. 2004 Apr;113(8):1168-75. doi: 10.1172/JCI20978. J Clin Invest. 2004. PMID: 15085196 Free PMC article.

7

Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9.

Rashid S, Curtis DE, Garuti R, Anderson NN, Bashmakov Y, Ho YK, Hammer RE, Moon YA, Horton JD. Rashid S, et al. Among authors: horton jd. Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5374-9. doi: 10.1073/pnas.0501652102. Epub 2005 Apr 1. Proc Natl Acad Sci U S A. 2005. PMID: 15805190 Free PMC article.

8

Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver.

Kuriyama H, Liang G, Engelking LJ, Horton JD, Goldstein JL, Brown MS. Kuriyama H, et al. Among authors: horton jd. Cell Metab. 2005 Jan;1(1):41-51. doi: 10.1016/j.cmet.2004.11.004. Cell Metab. 2005. PMID: 16054043 Free article.

9

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.

Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, Evers BM, Li WP, Horton JD, Goldstein JL, Brown MS. Engelking LJ, et al. Among authors: horton jd. J Clin Invest. 2005 Sep;115(9):2489-98. doi: 10.1172/JCI25614. Epub 2005 Aug 11. J Clin Invest. 2005. PMID: 16100574 Free PMC article.

10

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice.

Lagace TA, Curtis DE, Garuti R, McNutt MC, Park SW, Prather HB, Anderson NN, Ho YK, Hammer RE, Horton JD. Lagace TA, et al. Among authors: horton jd. J Clin Invest. 2006 Nov;116(11):2995-3005. doi: 10.1172/JCI29383. J Clin Invest. 2006. PMID: 17080197 Free PMC article.

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