Déglon N - Search Results

1

AAV5-miHTT gene therapy demonstrates suppression of mutant huntingtin aggregation and neuronal dysfunction in a rat model of Huntington's disease.

Miniarikova J, Zimmer V, Martier R, Brouwers CC, Pythoud C, Richetin K, Rey M, Lubelski J, Evers MM, van Deventer SJ, Petry H, Déglon N, Konstantinova P. Miniarikova J, et al. Among authors: deglon n. Gene Ther. 2017 Oct;24(10):630-639. doi: 10.1038/gt.2017.71. Epub 2017 Aug 3. Gene Ther. 2017. PMID: 28771234 Free PMC article.

2

Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease.

Déglon N, Tseng JL, Bensadoun JC, Zurn AD, Arsenijevic Y, Pereira de Almeida L, Zufferey R, Trono D, Aebischer P. Déglon N, et al. Hum Gene Ther. 2000 Jan 1;11(1):179-90. doi: 10.1089/10430340050016256. Hum Gene Ther. 2000. PMID: 10646649

3

Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease.

Régulier E, Pereira de Almeida L, Sommer B, Aebischer P, Déglon N. Régulier E, et al. Among authors: deglon n. Hum Gene Ther. 2002 Nov 1;13(16):1981-90. doi: 10.1089/10430340260355383. Hum Gene Ther. 2002. PMID: 12427308

4

Lentiviral-mediated RNA interference.

Abbas-Terki T, Blanco-Bose W, Déglon N, Pralong W, Aebischer P. Abbas-Terki T, et al. Among authors: deglon n. Hum Gene Ther. 2002 Dec 10;13(18):2197-201. doi: 10.1089/104303402320987888. Hum Gene Ther. 2002. PMID: 12542850

5

Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum.

Régulier E, Trottier Y, Perrin V, Aebischer P, Déglon N. Régulier E, et al. Among authors: deglon n. Hum Mol Genet. 2003 Nov 1;12(21):2827-36. doi: 10.1093/hmg/ddg305. Epub 2003 Sep 2. Hum Mol Genet. 2003. PMID: 12952868

6

Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: results of a phase I study.

Bloch J, Bachoud-Lévi AC, Déglon N, Lefaucheur JP, Winkel L, Palfi S, Nguyen JP, Bourdet C, Gaura V, Remy P, Brugières P, Boisse MF, Baudic S, Cesaro P, Hantraye P, Aebischer P, Peschanski M. Bloch J, et al. Among authors: deglon n. Hum Gene Ther. 2004 Oct;15(10):968-75. doi: 10.1089/hum.2004.15.968. Hum Gene Ther. 2004. PMID: 15585112 Clinical Trial.

7

Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment.

Zala D, Benchoua A, Brouillet E, Perrin V, Gaillard MC, Zurn AD, Aebischer P, Déglon N. Zala D, et al. Among authors: deglon n. Neurobiol Dis. 2005 Dec;20(3):785-98. doi: 10.1016/j.nbd.2005.05.017. Epub 2005 Jul 11. Neurobiol Dis. 2005. PMID: 16006135

8

Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease.

Perrin V, Régulier E, Abbas-Terki T, Hassig R, Brouillet E, Aebischer P, Luthi-Carter R, Déglon N. Perrin V, et al. Among authors: deglon n. Mol Ther. 2007 May;15(5):903-11. doi: 10.1038/mt.sj.6300141. Epub 2007 Mar 20. Mol Ther. 2007. PMID: 17375066 Free article.

9

Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates.

Palfi S, Brouillet E, Jarraya B, Bloch J, Jan C, Shin M, Condé F, Li XJ, Aebischer P, Hantraye P, Déglon N. Palfi S, et al. Among authors: deglon n. Mol Ther. 2007 Aug;15(8):1444-51. doi: 10.1038/sj.mt.6300185. Epub 2007 May 1. Mol Ther. 2007. PMID: 17505477 Free article.

10

Implication of the JNK pathway in a rat model of Huntington's disease.

Perrin V, Dufour N, Raoul C, Hassig R, Brouillet E, Aebischer P, Luthi-Carter R, Déglon N. Perrin V, et al. Among authors: deglon n. Exp Neurol. 2009 Jan;215(1):191-200. doi: 10.1016/j.expneurol.2008.10.008. Epub 2008 Oct 28. Exp Neurol. 2009. PMID: 19022249

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