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Loss of MutL Disrupts CHK2-Dependent Cell-Cycle Control through CDK4/6 to Promote Intrinsic Endocrine Therapy Resistance in Primary Breast Cancer.
Haricharan S, Punturi N, Singh P, Holloway KR, Anurag M, Schmelz J, Schmidt C, Lei JT, Suman V, Hunt K, Olson JA Jr, Hoog J, Li S, Huang S, Edwards DP, Kavuri SM, Bainbridge MN, Ma CX, Ellis MJ. Haricharan S, et al. Among authors: huang s. Cancer Discov. 2017 Oct;7(10):1168-1183. doi: 10.1158/2159-8290.CD-16-1179. Epub 2017 Aug 11. Cancer Discov. 2017. PMID: 28801307 Free PMC article.
The REGγ proteasome regulates hepatic lipid metabolism through inhibition of autophagy.
Dong S, Jia C, Zhang S, Fan G, Li Y, Shan P, Sun L, Xiao W, Li L, Zheng Y, Liu J, Wei H, Hu C, Zhang W, Chin YE, Zhai Q, Li Q, Liu J, Jia F, Mo Q, Edwards DP, Huang S, Chan L, O'Malley BW, Li X, Wang C. Dong S, et al. Among authors: huang s. Cell Metab. 2013 Sep 3;18(3):380-91. doi: 10.1016/j.cmet.2013.08.012. Cell Metab. 2013. PMID: 24011073 Free PMC article.
Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy.
Haricharan S, Dong J, Hein S, Reddy JP, Du Z, Toneff M, Holloway K, Hilsenbeck SG, Huang S, Atkinson R, Woodward W, Jindal S, Borges VF, Gutierrez C, Zhang H, Schedin PJ, Osborne CK, Tweardy DJ, Li Y. Haricharan S, et al. Among authors: huang s. Elife. 2013 Dec 31;2:e00996. doi: 10.7554/eLife.00996. Elife. 2013. PMID: 24381245 Free PMC article.
Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation.
Welte T, Kim IS, Tian L, Gao X, Wang H, Li J, Holdman XB, Herschkowitz JI, Pond A, Xie G, Kurley S, Nguyen T, Liao L, Dobrolecki LE, Pang L, Mo Q, Edwards DP, Huang S, Xin L, Xu J, Li Y, Lewis MT, Wang T, Westbrook TF, Rosen JM, Zhang XH. Welte T, et al. Among authors: huang s. Nat Cell Biol. 2016 Jun;18(6):632-44. doi: 10.1038/ncb3355. Epub 2016 May 16. Nat Cell Biol. 2016. PMID: 27183469 Free PMC article.
Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer.
Kaushik AK, Shojaie A, Panzitt K, Sonavane R, Venghatakrishnan H, Manikkam M, Zaslavsky A, Putluri V, Vasu VT, Zhang Y, Khan AS, Lloyd S, Szafran AT, Dasgupta S, Bader DA, Stossi F, Li H, Samanta S, Cao X, Tsouko E, Huang S, Frigo DE, Chan L, Edwards DP, Kaipparettu BA, Mitsiades N, Weigel NL, Mancini M, McGuire SE, Mehra R, Ittmann MM, Chinnaiyan AM, Putluri N, Palapattu GS, Michailidis G, Sreekumar A. Kaushik AK, et al. Among authors: huang s. Nat Commun. 2016 May 19;7:11612. doi: 10.1038/ncomms11612. Nat Commun. 2016. PMID: 27194471 Free PMC article.
Generation of an in vitro 3D PDAC stroma rich spheroid model.
Ware MJ, Keshishian V, Law JJ, Ho JC, Favela CA, Rees P, Smith B, Mohammad S, Hwang RF, Rajapakshe K, Coarfa C, Huang S, Edwards DP, Corr SJ, Godin B, Curley SA. Ware MJ, et al. Among authors: huang s. Biomaterials. 2016 Nov;108:129-42. doi: 10.1016/j.biomaterials.2016.08.041. Epub 2016 Sep 2. Biomaterials. 2016. PMID: 27627810 Free PMC article.
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