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Escape of Tick-Borne Flavivirus from 2'-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness.
Eyer L, Kondo H, Zouharova D, Hirano M, Valdés JJ, Muto M, Kastl T, Kobayashi S, Haviernik J, Igarashi M, Kariwa H, Vaculovicova M, Cerny J, Kizek R, Kröger A, Lienenklaus S, Dejmek M, Nencka R, Palus M, Salat J, De Clercq E, Yoshii K, Ruzek D. Eyer L, et al. Among authors: nencka r. J Virol. 2017 Oct 13;91(21):e01028-17. doi: 10.1128/JVI.01028-17. Print 2017 Nov 1. J Virol. 2017. PMID: 28814513 Free PMC article.
SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors.
Sála M, De Palma AM, Hřebabecký H, Dejmek M, Dračínský M, Leyssen P, Neyts J, Mertlíková-Kaiserová H, Nencka R. Sála M, et al. Among authors: nencka r. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4271-5. doi: 10.1016/j.bmcl.2011.05.070. Epub 2011 May 27. Bioorg Med Chem Lett. 2011. PMID: 21684160
Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose.
Dvorakova M, Nencka R, Dejmek M, Zbornikova E, Brezinova A, Pribylova M, Pohl R, Migaud ME, Vanek T. Dvorakova M, et al. Among authors: nencka r. Org Biomol Chem. 2013 Sep 14;11(34):5702-13. doi: 10.1039/c3ob41016a. Org Biomol Chem. 2013. PMID: 23884430
Synthesis of novel purine-based coxsackievirus inhibitors bearing polycylic substituents at the N-9 position.
Dejmek M, Sála M, Plačková P, Hřebabecký H, Mascarell Borredà L, Neyts J, Dračínský M, Procházková E, Jansa P, Leyssen P, Mertlíková-Kaiserová H, Nencka R. Dejmek M, et al. Among authors: nencka r. Arch Pharm (Weinheim). 2014 Jul;347(7):478-85. doi: 10.1002/ardp.201300431. Epub 2014 Mar 20. Arch Pharm (Weinheim). 2014. PMID: 24652670
Norbornane-based nucleoside and nucleotide analogues locked in North conformation.
Dejmek M, Šála M, Hřebabecký H, Dračínský M, Procházková E, Chalupská D, Klíma M, Plačková P, Hájek M, Andrei G, Naesens L, Leyssen P, Neyts J, Balzarini J, Boura E, Nencka R. Dejmek M, et al. Among authors: nencka r. Bioorg Med Chem. 2015 Jan 1;23(1):184-91. doi: 10.1016/j.bmc.2014.11.011. Epub 2014 Nov 15. Bioorg Med Chem. 2015. PMID: 25435471
Nucleoside inhibitors of tick-borne encephalitis virus.
Eyer L, Valdés JJ, Gil VA, Nencka R, Hřebabecký H, Šála M, Salát J, Černý J, Palus M, De Clercq E, Růžek D. Eyer L, et al. Among authors: nencka r. Antimicrob Agents Chemother. 2015 Sep;59(9):5483-93. doi: 10.1128/AAC.00807-15. Epub 2015 Jun 29. Antimicrob Agents Chemother. 2015. PMID: 26124166 Free PMC article.
The high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design.
Klima M, Baumlova A, Chalupska D, Hřebabecký H, Dejmek M, Nencka R, Boura E. Klima M, et al. Among authors: nencka r. Acta Crystallogr D Biol Crystallogr. 2015 Jul;71(Pt 7):1555-63. doi: 10.1107/S1399004715009505. Epub 2015 Jun 30. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 26143926
84 results